DegronMD

Uniprot ID: Q8TE56

Source protein: A disintegrin and metalloproteinase with thrombospondin motifs 17

Source gene: ADAMTS17

Class: DEG_SCF_FBW7_1

Location: 186:191

E3 ligase: FBXW7

DEGRON score: 0.9711

ASA_SCORE: 84.0167

COIL: 0.9332

CONS_SCORE: 0.4136

DSS_SCORE: 0.5203

HELIX: 0.0462

FCONS_SCORE: 1.1287

RIG_SCORE: 0.6394

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E193K	TCGA-34-2596	LUSC	TCGA	LTPSPS	DEG_SCF_FBW7_1	0.2778
p.E193K	DO26508	LUSC	ICGC	LTPSPS	DEG_SCF_FBW7_1	0.2778
p.H178L	TCGA-43-8118	LUSC	TCGA	LTPSPS	DEG_SCF_FBW7_1	0.1111
p.H178L	DO45471	LUSC	ICGC	LTPSPS	DEG_SCF_FBW7_1	0.1111
p.C201F	TCGA-CK-4951	COAD	TCGA	LTPSPS	DEG_SCF_FBW7_1	0.0556
p.C201F	DO10582	COAD	ICGC	LTPSPS	DEG_SCF_FBW7_1	0.0556
p.L200P	TCGA-DF-A2KN	UCEC	TCGA	LTPSPS	DEG_SCF_FBW7_1	0.0833
p.L200P	DO223282	UCEC	ICGC	LTPSPS	DEG_SCF_FBW7_1	0.0833
p.S185F	TCGA-EE-A2GR	SKCM	TCGA	LTPSPS	DEG_SCF_FBW7_1	0.3056
p.S185F	DO37996	SKCM	ICGC	LTPSPS	DEG_SCF_FBW7_1	0.3056
p.S189N	DO234462	ESAD	ICGC	LTPSPS	DEG_SCF_FBW7_1	0.5958
p.T187I	DO11854	GBM	ICGC	LTPSPS	DEG_SCF_FBW7_1	0.7078
p.R182S	DO229041	LICA	ICGC	LTPSPS	DEG_SCF_FBW7_1	0.2222
p.R176Q	SIDM01104	Melanoma	GDSC	LTPSPS	DEG_SCF_FBW7_1	0.0556
p.R176Q	SIDM01051	Ovarian Carcinoma	GDSC	LTPSPS	DEG_SCF_FBW7_1	0.0556
p.R176Q	ACH-000640	Skin Cancer	CCLE	LTPSPS	DEG_SCF_FBW7_1	0.0556
p.R176Q	ACH-000936	Ovarian Cancer	CCLE	LTPSPS	DEG_SCF_FBW7_1	0.0556
p.R176Q	EFO-27	ovary	COSMIC	LTPSPS	DEG_SCF_FBW7_1	0.0556
p.R176Q	SK-MEL-31	skin	COSMIC	LTPSPS	DEG_SCF_FBW7_1	0.0556
p.K183R	SIDM00662	Melanoma	GDSC	LTPSPS	DEG_SCF_FBW7_1	0.3611
p.K183R	SIDM00845	Burkitt's Lymphoma	GDSC	LTPSPS	DEG_SCF_FBW7_1	0.3611
p.K183R	SIDM01071	Small Cell Lung Carcinoma	GDSC	LTPSPS	DEG_SCF_FBW7_1	0.3611
p.K183R	SIDM00121	T-Lymphoblastic Leukemia	GDSC	LTPSPS	DEG_SCF_FBW7_1	0.3611
p.K183R	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	LTPSPS	DEG_SCF_FBW7_1	0.3611
p.K183R	SIDM01763	Rhabdomyosarcoma	GDSC	LTPSPS	DEG_SCF_FBW7_1	0.3611
p.T187N	SIDM00504	Glioma	GDSC	LTPSPS	DEG_SCF_FBW7_1	0.7055
p.T187N	ACH-001126	Brain Cancer	CCLE	LTPSPS	DEG_SCF_FBW7_1	0.7055
p.T187N	MOG-G-UVW	central_nervous_system	COSMIC	LTPSPS	DEG_SCF_FBW7_1	0.7055
p.R181K	SIDM01010	T-Cell Non-Hodgkin's Lymphoma	GDSC	LTPSPS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TE56	A disintegrin and metalloproteinase with thrombospondin motifs 17	DEG_SCF_FBW7_1	186:191	LTPSPS	FBXW7	0.9711	More...
Q711Q0	Cardiac-enriched FHL2-interacting protein	DEG_SCF_FBW7_1	841:846	LTPSPS	FBXW7	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPSPS

Degron related mutations and impact score

Drug responses associated with ADAMTS17 mutations

All proteins holding degron of LTPSPS