DegronMD - Q711Q0(CEFIP)

GO - Biological processes (BP): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1135W	DO229389	BTCA	ICGC	PRGSLLDVA	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.2222
p.T1136A	DO227844	COCA	ICGC	PRGSLLDVA	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.25
p.A1147T	DO233855	GACA	ICGC	PRGSLLDVA	DEG_APCC_DBOX_1	1139:1147	Mutation altering degron motif	0.6028
p.A838S	DO229038	LICA	ICGC	LTPSPS	DEG_SCF_FBW7_1	841:846	Mutation rewiring degron network	0.25
p.V1146L	DO229037	LICA	ICGC	PRGSLLDVA	DEG_APCC_DBOX_1	1139:1147	Mutation altering degron motif	0.5654
p.L1143F	DO46376	OV	ICGC	PRGSLLDVA	DEG_APCC_DBOX_1	1139:1147	Mutation altering degron motif	0.6981
p.S1138F	DO37782	SKCM	ICGC	PRGSLLDVA	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.3056
p.S1154P	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	PRGSLLDVA	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1389
p.S1154P	ACH-000837	Lung Cancer	CCLE	PRGSLLDVA	DEG_APCC_DBOX_1	1139:1147	Mutation rewiring degron network	0.1389
p.A838P	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	LTPSPS	DEG_SCF_FBW7_1	841:846	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons