DegronMD

Uniprot ID: Q711Q0

Source protein: Cardiac-enriched FHL2-interacting protein

Source gene: CEFIP

Class: DEG_APCC_DBOX_1

Location: 1139:1147

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8257

ASA_SCORE: 80.0333

COIL: 0.7757

CONS_SCORE: 0.5873

DSS_SCORE: 0.4692

HELIX: 0.179

FCONS_SCORE: 1.0075

RIG_SCORE: 0.6985

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1135W	DO229389	BTCA	ICGC	PRGSLLDVA	DEG_APCC_DBOX_1	0.2222
p.T1136A	DO227844	COCA	ICGC	PRGSLLDVA	DEG_APCC_DBOX_1	0.25
p.A1147T	DO233855	GACA	ICGC	PRGSLLDVA	DEG_APCC_DBOX_1	0.6028
p.V1146L	DO229037	LICA	ICGC	PRGSLLDVA	DEG_APCC_DBOX_1	0.5654
p.L1143F	DO46376	OV	ICGC	PRGSLLDVA	DEG_APCC_DBOX_1	0.6981
p.S1138F	DO37782	SKCM	ICGC	PRGSLLDVA	DEG_APCC_DBOX_1	0.3056
p.S1154P	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	PRGSLLDVA	DEG_APCC_DBOX_1	0.1389
p.S1154P	ACH-000837	Lung Cancer	CCLE	PRGSLLDVA	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q711Q0	Cardiac-enriched FHL2-interacting protein	DEG_APCC_DBOX_1	1139:1147	PRGSLLDVA	APC,CDC20,FZR1	0.8257	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons