DegronMD - Q8TE82(SH3TC1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D116N	TCGA-5L-AAT1	BRCA	TCGA	LRGQLRLLE	DEG_APCC_DBOX_1	106:114	Mutation rewiring degron network	0.2778
p.D116N	DO219594	BRCA	ICGC	LRGQLRLLE	DEG_APCC_DBOX_1	106:114	Mutation rewiring degron network	0.2778
p.R98L	TCGA-D3-A2JG	SKCM	TCGA	LRGQLRLLE	DEG_APCC_DBOX_1	106:114	Mutation rewiring degron network	0.1111
p.R98L	DO47613	SKCM	ICGC	LRGQLRLLE	DEG_APCC_DBOX_1	106:114	Mutation rewiring degron network	0.1111
p.R107W	TCGA-FZ-5921	PAAD	TCGA	LRGQLRLLE	DEG_APCC_DBOX_1	106:114	Mutation altering degron motif	0.8634
p.V101I	DO233855	GACA	ICGC	LRGQLRLLE	DEG_APCC_DBOX_1	106:114	Mutation rewiring degron network	0.1944
p.V108F	DO228978	LICA	ICGC	LRGQLRLLE	DEG_APCC_DBOX_1	106:114	Mutation altering degron motif	0.7068
p.W107L	DO24320	LUAD	ICGC	LRGQLRLLE	DEG_APCC_DBOX_1	106:114	Mutation altering degron motif	0.7015
p.T105N	DO229232	THCA	ICGC	LRGQLRLLE	DEG_APCC_DBOX_1	106:114	Mutation rewiring degron network	0.3056
p.G101S	DO43218	UCEC	ICGC	LRGQLRLLE	DEG_APCC_DBOX_1	106:114	Mutation rewiring degron network	0.1944
p.G101S	ACH-002024	Colon/Colorectal Cancer	CCLE	LRGQLRLLE	DEG_APCC_DBOX_1	106:114	Mutation rewiring degron network	0.1944
p.R98Q	SIDM00499	Prostate Carcinoma	GDSC	LRGQLRLLE	DEG_APCC_DBOX_1	106:114	Mutation rewiring degron network	0.1111
p.R98Q	SIDM00566	Oral Cavity Carcinoma	GDSC	LRGQLRLLE	DEG_APCC_DBOX_1	106:114	Mutation rewiring degron network	0.1111
p.R98Q	SIDM00289	B-Lymphoblastic Leukemia	GDSC	LRGQLRLLE	DEG_APCC_DBOX_1	106:114	Mutation rewiring degron network	0.1111
p.R98Q	SIDM01444	Glioblastoma	GDSC	LRGQLRLLE	DEG_APCC_DBOX_1	106:114	Mutation rewiring degron network	0.1111
p.R98Q	OSC-19	upper aerodigestive tract	COSMIC	LRGQLRLLE	DEG_APCC_DBOX_1	106:114	Mutation rewiring degron network	0.1111
p.R98Q	22RV1	prostate	COSMIC	LRGQLRLLE	DEG_APCC_DBOX_1	106:114	Mutation rewiring degron network	0.1111
p.R98Q	HAL-01	haematopoietic and lymphoid tissue	COSMIC	LRGQLRLLE	DEG_APCC_DBOX_1	106:114	Mutation rewiring degron network	0.1111
p.R122H	SIDM01180	Hepatocellular Carcinoma	GDSC	LRGQLRLLE	DEG_APCC_DBOX_1	106:114	Mutation rewiring degron network	0.1111
p.V123M	ACH-001289	Rhabdoid	CCLE	LRGQLRLLE	DEG_APCC_DBOX_1	106:114	Mutation rewiring degron network	0.0833
p.R107Q	HCC-56	large intestine	COSMIC	LRGQLRLLE	DEG_APCC_DBOX_1	106:114	Mutation altering degron motif	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SH3TC1

UniProt ID: Q8TE82

Entrez ID: 54436

Protein name: SH3 domain and tetratricopeptide repeat-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SH3TC1 in