DegronMD

Uniprot ID: Q8TE82

Source protein: SH3 domain and tetratricopeptide repeat-containing protein 1

Source gene: SH3TC1

Class: DEG_APCC_DBOX_1

Location: 106:114

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7593

ASA_SCORE: 56.0889

COIL: 0.1186

CONS_SCORE: 0.6687

DSS_SCORE: 0.3401

HELIX: 0.8748

FCONS_SCORE: 1.2129

RIG_SCORE: 0.7865

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D116N	TCGA-5L-AAT1	BRCA	TCGA	LRGQLRLLE	DEG_APCC_DBOX_1	0.2778
p.D116N	DO219594	BRCA	ICGC	LRGQLRLLE	DEG_APCC_DBOX_1	0.2778
p.R98L	TCGA-D3-A2JG	SKCM	TCGA	LRGQLRLLE	DEG_APCC_DBOX_1	0.1111
p.R98L	DO47613	SKCM	ICGC	LRGQLRLLE	DEG_APCC_DBOX_1	0.1111
p.R107W	TCGA-FZ-5921	PAAD	TCGA	LRGQLRLLE	DEG_APCC_DBOX_1	0.8634
p.V101I	DO233855	GACA	ICGC	LRGQLRLLE	DEG_APCC_DBOX_1	0.1944
p.V108F	DO228978	LICA	ICGC	LRGQLRLLE	DEG_APCC_DBOX_1	0.7068
p.W107L	DO24320	LUAD	ICGC	LRGQLRLLE	DEG_APCC_DBOX_1	0.7015
p.T105N	DO229232	THCA	ICGC	LRGQLRLLE	DEG_APCC_DBOX_1	0.3056
p.G101S	DO43218	UCEC	ICGC	LRGQLRLLE	DEG_APCC_DBOX_1	0.1944
p.G101S	ACH-002024	Colon/Colorectal Cancer	CCLE	LRGQLRLLE	DEG_APCC_DBOX_1	0.1944
p.R98Q	SIDM00499	Prostate Carcinoma	GDSC	LRGQLRLLE	DEG_APCC_DBOX_1	0.1111
p.R98Q	SIDM00566	Oral Cavity Carcinoma	GDSC	LRGQLRLLE	DEG_APCC_DBOX_1	0.1111
p.R98Q	SIDM00289	B-Lymphoblastic Leukemia	GDSC	LRGQLRLLE	DEG_APCC_DBOX_1	0.1111
p.R98Q	SIDM01444	Glioblastoma	GDSC	LRGQLRLLE	DEG_APCC_DBOX_1	0.1111
p.R98Q	OSC-19	upper_aerodigestive_tract	COSMIC	LRGQLRLLE	DEG_APCC_DBOX_1	0.1111
p.R98Q	22RV1	prostate	COSMIC	LRGQLRLLE	DEG_APCC_DBOX_1	0.1111
p.R98Q	HAL-01	haematopoietic_and_lymphoid_tissue	COSMIC	LRGQLRLLE	DEG_APCC_DBOX_1	0.1111
p.R122H	SIDM01180	Hepatocellular Carcinoma	GDSC	LRGQLRLLE	DEG_APCC_DBOX_1	0.1111
p.V123M	ACH-001289	Rhabdoid	CCLE	LRGQLRLLE	DEG_APCC_DBOX_1	0.0833
p.R107Q	HCC-56	large_intestine	COSMIC	LRGQLRLLE	DEG_APCC_DBOX_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TE82	SH3 domain and tetratricopeptide repeat-containing protein 1	DEG_APCC_DBOX_1	106:114	LRGQLRLLE	APC,CDC20,FZR1	0.7593	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons