DegronMD - Q8TE85(GRHL3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E115D	TCGA-06-5416	GBM	TCGA	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.0556
p.E115D	TCGA-B5-A11N	UCEC	TCGA	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.0556
p.E115D	DO10880	GBM	ICGC	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.0556
p.E115D	DO41458	UCEC	ICGC	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.0556
p.P102T	TCGA-18-3410	LUSC	TCGA	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation altering degron motif	0.7031
p.P102T	DO26456	LUSC	ICGC	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation altering degron motif	0.7031
p.E97Q	TCGA-55-7913	LUAD	TCGA	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.25
p.E97Q	DO223665	LUAD	ICGC	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.25
p.T98M	TCGA-85-7710	LUSC	TCGA	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.2778
p.T98M	TCGA-B8-A54E	KIRC	TCGA	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.2778
p.T98M	DO50478	KIRC	ICGC	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.2778
p.T98M	DO26826	LUSC	ICGC	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.2778
p.L103I	TCGA-DB-5270	LGG	TCGA	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation altering degron motif	0.6063
p.L103I	DO22745	LGG	ICGC	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation altering degron motif	0.6063
p.P102A	DO228260	BRCA	ICGC	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation altering degron motif	0.7503
p.M94T	DO233898	GACA	ICGC	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.1667
p.P102L	DO222843	MELA	ICGC	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation altering degron motif	0.7582
p.T114I	SIDM00683	Prostate Carcinoma	GDSC	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.0833
p.T114I	ACH-000977	lymph node	CCLE	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.0833
p.T114I	LNCaP-Clone-FGC	prostate	COSMIC	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.0833
p.T101I	SIDM00846	Cervical Carcinoma	GDSC	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation altering degron motif	0.7078
p.T101I	ACH-001086	Cervical Cancer	CCLE	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation altering degron motif	0.7078
p.T101I	HeLa	cervix	COSMIC	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation altering degron motif	0.7078
p.L93V	LS-180	large intestine	COSMIC	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.1389
p.T106I	HeLa	cervix	COSMIC	LTPLES	DEG_SCF_FBW7_1	100:105	Mutation rewiring degron network	0.3056

Kaplan plot for GRHL3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GRHL3

UniProt ID: Q8TE85

Entrez ID: 57822

Protein name: Grainyhead-like protein 3 homolog (Sister of mammalian grainyhead) (Transcription factor CP2-like 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GRHL3 in