DegronMD

Uniprot ID: Q8TE85

Source protein: Grainyhead-like protein 3 homolog

Source gene: GRHL3

Class: DEG_SCF_FBW7_1

Location: 100:105

E3 ligase: FBXW7

DEGRON score: 0.9894

ASA_SCORE: 72.75

COIL: 0.8668

CONS_SCORE: 0.3138

DSS_SCORE: 0.4243

HELIX: 0.0673

FCONS_SCORE: 0.9096

RIG_SCORE: 0.7334

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E115D	TCGA-06-5416	GBM	TCGA	LTPLES	DEG_SCF_FBW7_1	0.0556
p.E115D	TCGA-B5-A11N	UCEC	TCGA	LTPLES	DEG_SCF_FBW7_1	0.0556
p.E115D	DO10880	GBM	ICGC	LTPLES	DEG_SCF_FBW7_1	0.0556
p.E115D	DO41458	UCEC	ICGC	LTPLES	DEG_SCF_FBW7_1	0.0556
p.P102T	TCGA-18-3410	LUSC	TCGA	LTPLES	DEG_SCF_FBW7_1	0.7031
p.P102T	DO26456	LUSC	ICGC	LTPLES	DEG_SCF_FBW7_1	0.7031
p.E97Q	TCGA-55-7913	LUAD	TCGA	LTPLES	DEG_SCF_FBW7_1	0.25
p.E97Q	DO223665	LUAD	ICGC	LTPLES	DEG_SCF_FBW7_1	0.25
p.T98M	TCGA-85-7710	LUSC	TCGA	LTPLES	DEG_SCF_FBW7_1	0.2778
p.T98M	TCGA-B8-A54E	KIRC	TCGA	LTPLES	DEG_SCF_FBW7_1	0.2778
p.T98M	DO50478	KIRC	ICGC	LTPLES	DEG_SCF_FBW7_1	0.2778
p.T98M	DO26826	LUSC	ICGC	LTPLES	DEG_SCF_FBW7_1	0.2778
p.L103I	TCGA-DB-5270	LGG	TCGA	LTPLES	DEG_SCF_FBW7_1	0.6063
p.L103I	DO22745	LGG	ICGC	LTPLES	DEG_SCF_FBW7_1	0.6063
p.P102A	DO228260	BRCA	ICGC	LTPLES	DEG_SCF_FBW7_1	0.7503
p.M94T	DO233898	GACA	ICGC	LTPLES	DEG_SCF_FBW7_1	0.1667
p.P102L	DO222843	MELA	ICGC	LTPLES	DEG_SCF_FBW7_1	0.7582
p.T114I	SIDM00683	Prostate Carcinoma	GDSC	LTPLES	DEG_SCF_FBW7_1	0.0833
p.T114I	ACH-000977	lymph_node	CCLE	LTPLES	DEG_SCF_FBW7_1	0.0833
p.T114I	LNCaP-Clone-FGC	prostate	COSMIC	LTPLES	DEG_SCF_FBW7_1	0.0833
p.T101I	SIDM00846	Cervical Carcinoma	GDSC	LTPLES	DEG_SCF_FBW7_1	0.7078
p.T101I	ACH-001086	Cervical Cancer	CCLE	LTPLES	DEG_SCF_FBW7_1	0.7078
p.T101I	HeLa	cervix	COSMIC	LTPLES	DEG_SCF_FBW7_1	0.7078
p.L93V	LS-180	large_intestine	COSMIC	LTPLES	DEG_SCF_FBW7_1	0.1389
p.T106I	HeLa	cervix	COSMIC	LTPLES	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TE85	Grainyhead-like protein 3 homolog	DEG_SCF_FBW7_1	100:105	LTPLES	FBXW7	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons