DegronMD - Q8TEB7(RNF128)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D401G	TCGA-06-0213	GBM	TCGA	VIPHVD	LIG_APCC_ABBA_1	402:407	Mutation rewiring degron network	0.3056
p.D401G	DO11836	GBM	ICGC	VIPHVD	LIG_APCC_ABBA_1	402:407	Mutation rewiring degron network	0.3056
p.N408K	TCGA-44-2657	LUAD	TCGA	VIPHVD	LIG_APCC_ABBA_1	402:407	Mutation rewiring degron network	0.3056
p.N408K	ACH-000560	Gastric Cancer	CCLE	VIPHVD	LIG_APCC_ABBA_1	402:407	Mutation rewiring degron network	0.3056
p.N408K	ECC10	stomach	COSMIC	VIPHVD	LIG_APCC_ABBA_1	402:407	Mutation rewiring degron network	0.3056
p.F411S	TCGA-AJ-A3EK	UCEC	TCGA	VIPHVD	LIG_APCC_ABBA_1	402:407	Mutation rewiring degron network	0.2222
p.S397Y	TCGA-AZ-4315	COAD	TCGA	VIPHVD	LIG_APCC_ABBA_1	402:407	Mutation rewiring degron network	0.1944
p.S397Y	DO8842	COAD	ICGC	VIPHVD	LIG_APCC_ABBA_1	402:407	Mutation rewiring degron network	0.1944
p.E415K	TCGA-EE-A2MJ	SKCM	TCGA	VIPHVD	LIG_APCC_ABBA_1	402:407	Mutation rewiring degron network	0.1111
p.E415K	DO38099	SKCM	ICGC	VIPHVD	LIG_APCC_ABBA_1	402:407	Mutation rewiring degron network	0.1111
p.N396K	TCGA-ND-A4WC	UCS	TCGA	VIPHVD	LIG_APCC_ABBA_1	402:407	Mutation rewiring degron network	0.1667
p.A396V	DO41109	UCEC	ICGC	VIPHVD	LIG_APCC_ABBA_1	402:407	Mutation rewiring degron network	0.1667
p.A396V	COLO-668	lung	COSMIC	VIPHVD	LIG_APCC_ABBA_1	402:407	Mutation rewiring degron network	0.1667
p.H393R	SIDM00630	Breast Carcinoma	GDSC	VIPHVD	LIG_APCC_ABBA_1	402:407	Mutation rewiring degron network	0.0833
p.H393R	ACH-000876	Breast Cancer	CCLE	VIPHVD	LIG_APCC_ABBA_1	402:407	Mutation rewiring degron network	0.0833
p.H393R	MDA-MB-415	breast	COSMIC	VIPHVD	LIG_APCC_ABBA_1	402:407	Mutation rewiring degron network	0.0833
p.I403V	SIDM00845	Burkitt's Lymphoma	GDSC	VIPHVD	LIG_APCC_ABBA_1	402:407	Mutation altering degron motif	0.5965
p.D407N	SIDM00489	Oral Cavity Carcinoma	GDSC	VIPHVD	LIG_APCC_ABBA_1	402:407	Mutation altering degron motif	0.6932
p.D407N	ACH-002043	Head and Neck Cancer	CCLE	VIPHVD	LIG_APCC_ABBA_1	402:407	Mutation altering degron motif	0.6932
p.D407N	Ca9-22	upper aerodigestive tract	COSMIC	VIPHVD	LIG_APCC_ABBA_1	402:407	Mutation altering degron motif	0.6932

Kaplan plot for RNF128 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RNF128

UniProt ID: Q8TEB7

Entrez ID: 79589

Protein name: E3 ubiquitin-protein ligase RNF128 (EC 2.3.2.27) (Gene related to anergy in lymphocytes protein) (GRAIL) (RING finger protein 128) (RING-type E3 ubiquitin transferase RNF128)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RNF128 in