DegronMD

Uniprot ID: Q8TEB7

Source protein: E3 ubiquitin-protein ligase RNF128

Source gene: RNF128

Class: LIG_APCC_ABBA_1

Location: 402:407

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.52

ASA_SCORE: 93.1167

COIL: 0.793

CONS_SCORE: 0.2933

DSS_SCORE: 0.5834

HELIX: 0.0108

FCONS_SCORE: 1.0043

RIG_SCORE: 0.7463

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D407N	SIDM00489	Oral Cavity Carcinoma	GDSC	VIPHVD	LIG_APCC_ABBA_1	0.6932
p.D407N	ACH-002043	Head and Neck Cancer	CCLE	VIPHVD	LIG_APCC_ABBA_1	0.6932
p.D407N	Ca9-22	upper_aerodigestive_tract	COSMIC	VIPHVD	LIG_APCC_ABBA_1	0.6932
p.I403V	SIDM00845	Burkitt's Lymphoma	GDSC	VIPHVD	LIG_APCC_ABBA_1	0.5965
p.D401G	TCGA-06-0213	GBM	TCGA	VIPHVD	LIG_APCC_ABBA_1	0.3056
p.D401G	DO11836	GBM	ICGC	VIPHVD	LIG_APCC_ABBA_1	0.3056
p.N408K	TCGA-44-2657	LUAD	TCGA	VIPHVD	LIG_APCC_ABBA_1	0.3056
p.N408K	ACH-000560	Gastric Cancer	CCLE	VIPHVD	LIG_APCC_ABBA_1	0.3056
p.N408K	ECC10	stomach	COSMIC	VIPHVD	LIG_APCC_ABBA_1	0.3056
p.F411S	TCGA-AJ-A3EK	UCEC	TCGA	VIPHVD	LIG_APCC_ABBA_1	0.2222
p.S397Y	TCGA-AZ-4315	COAD	TCGA	VIPHVD	LIG_APCC_ABBA_1	0.1944
p.S397Y	DO8842	COAD	ICGC	VIPHVD	LIG_APCC_ABBA_1	0.1944
p.N396K	TCGA-ND-A4WC	UCS	TCGA	VIPHVD	LIG_APCC_ABBA_1	0.1667
p.A396V	DO41109	UCEC	ICGC	VIPHVD	LIG_APCC_ABBA_1	0.1667
p.A396V	COLO-668	lung	COSMIC	VIPHVD	LIG_APCC_ABBA_1	0.1667
p.E415K	TCGA-EE-A2MJ	SKCM	TCGA	VIPHVD	LIG_APCC_ABBA_1	0.1111
p.E415K	DO38099	SKCM	ICGC	VIPHVD	LIG_APCC_ABBA_1	0.1111
p.H393R	SIDM00630	Breast Carcinoma	GDSC	VIPHVD	LIG_APCC_ABBA_1	0.0833
p.H393R	ACH-000876	Breast Cancer	CCLE	VIPHVD	LIG_APCC_ABBA_1	0.0833
p.H393R	MDA-MB-415	breast	COSMIC	VIPHVD	LIG_APCC_ABBA_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEB7	E3 ubiquitin-protein ligase RNF128	LIG_APCC_ABBA_1	402:407	VIPHVD	APC,CDC20,FZR1	0.52	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons