DegronMD - Q8TET4(GANC)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E97Q	TCGA-CN-A63W	HNSC	TCGA	INEETPLK	DEG_SCF_SKP2-CKS1_1	86:93	Mutation rewiring degron network	0.2222
p.E97Q	DO49031	HNSC	ICGC	INEETPLK	DEG_SCF_SKP2-CKS1_1	86:93	Mutation rewiring degron network	0.2222
p.G76C	TCGA-EE-A29X	SKCM	TCGA	INEETPLK	DEG_SCF_SKP2-CKS1_1	86:93	Mutation rewiring degron network	0.0556
p.G76C	DO37595	SKCM	ICGC	INEETPLK	DEG_SCF_SKP2-CKS1_1	86:93	Mutation rewiring degron network	0.0556
p.G79R	TCGA-YG-AA3N	SKCM	TCGA	INEETPLK	DEG_SCF_SKP2-CKS1_1	86:93	Mutation rewiring degron network	0.1389
p.G79R	DO51298	SKCM	ICGC	INEETPLK	DEG_SCF_SKP2-CKS1_1	86:93	Mutation rewiring degron network	0.1389
p.G79R	DO38404	STAD	ICGC	INEETPLK	DEG_SCF_SKP2-CKS1_1	86:93	Mutation rewiring degron network	0.1389
p.L92V	DO50323	ESAD	ICGC	INEETPLK	DEG_SCF_SKP2-CKS1_1	86:93	Mutation altering degron motif	0.5654
p.E88K	DO222500	ESCA	ICGC	INEETPLK	DEG_SCF_SKP2-CKS1_1	86:93	Mutation altering degron motif	0.7022
p.V101F	DO228952	LICA	ICGC	INEETPLK	DEG_SCF_SKP2-CKS1_1	86:93	Mutation rewiring degron network	0.1111
p.A102V	DO222743	MELA	ICGC	INEETPLK	DEG_SCF_SKP2-CKS1_1	86:93	Mutation rewiring degron network	0.0833
p.P91S	SIDM01245	T-Lymphoblastic Leukemia	GDSC	INEETPLK	DEG_SCF_SKP2-CKS1_1	86:93	Mutation altering degron motif	0.6752
p.P91S	SIDM00991	T-Lymphoblastic Leukemia	GDSC	INEETPLK	DEG_SCF_SKP2-CKS1_1	86:93	Mutation altering degron motif	0.6752
p.P91S	BE-13	haematopoietic and lymphoid tissue	COSMIC	INEETPLK	DEG_SCF_SKP2-CKS1_1	86:93	Mutation altering degron motif	0.6752
p.R95K	SIDM00261	Ewing's Sarcoma	GDSC	INEETPLK	DEG_SCF_SKP2-CKS1_1	86:93	Mutation rewiring degron network	0.2778
p.R95K	ES8	bone	COSMIC	INEETPLK	DEG_SCF_SKP2-CKS1_1	86:93	Mutation rewiring degron network	0.2778

Kaplan plot for GANC in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GANC

UniProt ID: Q8TET4

Entrez ID: 2595

Protein name: Neutral alpha-glucosidase C (EC 3.2.1.20)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GANC in