DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
INEETPLK
Uniprot ID:
Q8TET4
Source protein:
Neutral alpha-glucosidase C
Source gene:
GANC
Class:
DEG_SCF_SKP2-CKS1_1
Location:
86:93
E3 ligase:
SKP2,CSK1
DEGRON score:
0.6511
ASA_SCORE:
78.9625
COIL:
0.7168
CONS_SCORE:
0.3312
DSS_SCORE:
0.2047
HELIX:
0.0228
FCONS_SCORE:
0.8604
RIG_SCORE:
0.7996
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E97Q
TCGA-CN-A63W
HNSC
TCGA
INEETPLK
DEG_SCF_SKP2-CKS1_1
0.2222
p.E97Q
DO49031
HNSC
ICGC
INEETPLK
DEG_SCF_SKP2-CKS1_1
0.2222
p.G76C
TCGA-EE-A29X
SKCM
TCGA
INEETPLK
DEG_SCF_SKP2-CKS1_1
0.0556
p.G76C
DO37595
SKCM
ICGC
INEETPLK
DEG_SCF_SKP2-CKS1_1
0.0556
p.G79R
TCGA-YG-AA3N
SKCM
TCGA
INEETPLK
DEG_SCF_SKP2-CKS1_1
0.1389
p.G79R
DO51298
SKCM
ICGC
INEETPLK
DEG_SCF_SKP2-CKS1_1
0.1389
p.G79R
DO38404
STAD
ICGC
INEETPLK
DEG_SCF_SKP2-CKS1_1
0.1389
p.L92V
DO50323
ESAD
ICGC
INEETPLK
DEG_SCF_SKP2-CKS1_1
0.5654
p.E88K
DO222500
ESCA
ICGC
INEETPLK
DEG_SCF_SKP2-CKS1_1
0.7022
p.V101F
DO228952
LICA
ICGC
INEETPLK
DEG_SCF_SKP2-CKS1_1
0.1111
p.A102V
DO222743
MELA
ICGC
INEETPLK
DEG_SCF_SKP2-CKS1_1
0.0833
p.P91S
SIDM01245
T-Lymphoblastic Leukemia
GDSC
INEETPLK
DEG_SCF_SKP2-CKS1_1
0.6752
p.P91S
SIDM00991
T-Lymphoblastic Leukemia
GDSC
INEETPLK
DEG_SCF_SKP2-CKS1_1
0.6752
p.P91S
BE-13
haematopoietic_and_lymphoid_tissue
COSMIC
INEETPLK
DEG_SCF_SKP2-CKS1_1
0.6752
p.R95K
SIDM00261
Ewing's Sarcoma
GDSC
INEETPLK
DEG_SCF_SKP2-CKS1_1
0.2778
p.R95K
ES8
bone
COSMIC
INEETPLK
DEG_SCF_SKP2-CKS1_1
0.2778
Drug responses associated with GANC mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of INEETPLK
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8TET4
Neutral alpha-glucosidase C
DEG_SCF_SKP2-CKS1_1
86:93
INEETPLK
SKP2,CSK1
0.6511
More...