DegronMD - Q8TF21(ANKRD24)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S277G	TCGA-AP-A0LM	UCEC	TCGA	DSGEASS	DEG_SCF_TRCP1_1	283:289	Mutation rewiring degron network	0.1667
p.S294F	TCGA-EE-A29T	SKCM	TCGA	DSGEASS	DEG_SCF_TRCP1_1	283:289	Mutation rewiring degron network	0.1944
p.R288G	DO219096	BLCA	ICGC	DSGEASS	DEG_SCF_TRCP1_1	283:289	Mutation altering degron motif	0.7568
p.R288C	DO48199	ESCA	ICGC	DSGEASS	DEG_SCF_TRCP1_1	283:289	Mutation altering degron motif	0.8301
p.R288C	DO219477	SKCM	ICGC	DSGEASS	DEG_SCF_TRCP1_1	283:289	Mutation altering degron motif	0.8301
p.D299N	DO222423	MELA	ICGC	DSGEASS	DEG_SCF_TRCP1_1	283:289	Mutation rewiring degron network	0.0556
p.R288H	DO38723	STAD	ICGC	DSGEASS	DEG_SCF_TRCP1_1	283:289	Mutation altering degron motif	0.8244
p.A296V	DO42256	UCEC	ICGC	DSGEASS	DEG_SCF_TRCP1_1	283:289	Mutation rewiring degron network	0.1389
p.D282Y	SIDM00698	Small Cell Lung Carcinoma	GDSC	DSGEASS	DEG_SCF_TRCP1_1	283:289	Mutation rewiring degron network	0.3056
p.D282Y	ACH-000506	Lung Cancer	CCLE	DSGEASS	DEG_SCF_TRCP1_1	283:289	Mutation rewiring degron network	0.3056
p.D282Y	NCI-H146	lung	COSMIC	DSGEASS	DEG_SCF_TRCP1_1	283:289	Mutation rewiring degron network	0.3056
p.N291K	SIDM01588	Endometrial Carcinoma	GDSC	DSGEASS	DEG_SCF_TRCP1_1	283:289	Mutation rewiring degron network	0.2778
p.P274S	NCI-H1573	lung	COSMIC	DSGEASS	DEG_SCF_TRCP1_1	283:289	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons