DegronMD

Uniprot ID: Q8TF21

Source protein: Ankyrin repeat domain-containing protein 24

Source gene: ANKRD24

Class: DEG_SCF_TRCP1_1

Location: 283:289

E3 ligase: BTRC

DEGRON score: 0.9713

ASA_SCORE: 65.1571

COIL: 0.6024

CONS_SCORE: 0.5127

DSS_SCORE: 0.7803

HELIX: 0.3613

FCONS_SCORE: 1.3496

RIG_SCORE: 0.5315

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S277G	TCGA-AP-A0LM	UCEC	TCGA	DSGEASS	DEG_SCF_TRCP1_1	0.1667
p.S294F	TCGA-EE-A29T	SKCM	TCGA	DSGEASS	DEG_SCF_TRCP1_1	0.1944
p.R288G	DO219096	BLCA	ICGC	DSGEASS	DEG_SCF_TRCP1_1	0.7568
p.R288C	DO48199	ESCA	ICGC	DSGEASS	DEG_SCF_TRCP1_1	0.8301
p.R288C	DO219477	SKCM	ICGC	DSGEASS	DEG_SCF_TRCP1_1	0.8301
p.D299N	DO222423	MELA	ICGC	DSGEASS	DEG_SCF_TRCP1_1	0.0556
p.R288H	DO38723	STAD	ICGC	DSGEASS	DEG_SCF_TRCP1_1	0.8244
p.A296V	DO42256	UCEC	ICGC	DSGEASS	DEG_SCF_TRCP1_1	0.1389
p.D282Y	SIDM00698	Small Cell Lung Carcinoma	GDSC	DSGEASS	DEG_SCF_TRCP1_1	0.3056
p.D282Y	ACH-000506	Lung Cancer	CCLE	DSGEASS	DEG_SCF_TRCP1_1	0.3056
p.D282Y	NCI-H146	lung	COSMIC	DSGEASS	DEG_SCF_TRCP1_1	0.3056
p.N291K	SIDM01588	Endometrial Carcinoma	GDSC	DSGEASS	DEG_SCF_TRCP1_1	0.2778
p.P274S	NCI-H1573	lung	COSMIC	DSGEASS	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N350	Voltage-dependent calcium channel beta subunit-associated regulatory protein	DEG_SCF_TRCP1_1	185:191	DSGEASS	BTRC	0.9555	More...
Q8TF21	Ankyrin repeat domain-containing protein 24	DEG_SCF_TRCP1_1	283:289	DSGEASS	BTRC	0.9713	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons