DegronMD - Q8WTR7(ZNF473)

GO - Biological processes (BP): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F191S	TCGA-E9-A22B	BRCA	TCGA	LTPAKS	DEG_SCF_FBW7_1	178:183	Mutation rewiring degron network	0.1111
p.F191S	DO1454	BRCA	ICGC	LTPAKS	DEG_SCF_FBW7_1	178:183	Mutation rewiring degron network	0.1111
p.S168F	DO222798	COCA	ICGC	LTPAKS	DEG_SCF_FBW7_1	178:183	Mutation rewiring degron network	0.0556
p.V173F	DO228978	LICA	ICGC	LTPAKS	DEG_SCF_FBW7_1	178:183	Mutation rewiring degron network	0.1944
p.R187K	SIDM00636	Non-Cancerous	GDSC	LTPAKS	DEG_SCF_FBW7_1	178:183	Mutation rewiring degron network	0.2222
p.R187K	ACH-002270	Non-Cancerous	CCLE	LTPAKS	DEG_SCF_FBW7_1	178:183	Mutation rewiring degron network	0.2222
p.R187K	MC-CAR	haematopoietic and lymphoid tissue	COSMIC	LTPAKS	DEG_SCF_FBW7_1	178:183	Mutation rewiring degron network	0.2222
p.R175K	MC-CAR	haematopoietic and lymphoid tissue	COSMIC	LTPAKS	DEG_SCF_FBW7_1	178:183	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons