DegronMD

Uniprot ID: Q8WTR7

Source protein: Zinc finger protein 473

Source gene: ZNF473

Class: DEG_SCF_FBW7_1

Location: 178:183

E3 ligase: FBXW7

DEGRON score: 0.8953

ASA_SCORE: 67.9333

COIL: 0.5705

CONS_SCORE: 0.5658

DSS_SCORE: 0.4732

HELIX: 0.0277

FCONS_SCORE: 1.089

RIG_SCORE: 0.7275

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F191S	TCGA-E9-A22B	BRCA	TCGA	LTPAKS	DEG_SCF_FBW7_1	0.1111
p.F191S	DO1454	BRCA	ICGC	LTPAKS	DEG_SCF_FBW7_1	0.1111
p.S168F	DO222798	COCA	ICGC	LTPAKS	DEG_SCF_FBW7_1	0.0556
p.V173F	DO228978	LICA	ICGC	LTPAKS	DEG_SCF_FBW7_1	0.1944
p.R187K	SIDM00636	Non-Cancerous	GDSC	LTPAKS	DEG_SCF_FBW7_1	0.2222
p.R187K	ACH-002270	Non-Cancerous	CCLE	LTPAKS	DEG_SCF_FBW7_1	0.2222
p.R187K	MC-CAR	haematopoietic_and_lymphoid_tissue	COSMIC	LTPAKS	DEG_SCF_FBW7_1	0.2222
p.R175K	MC-CAR	haematopoietic_and_lymphoid_tissue	COSMIC	LTPAKS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WTR7	Zinc finger protein 473	DEG_SCF_FBW7_1	178:183	LTPAKS	FBXW7	0.8953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons