DegronMD - Q8WTT2(NOC3L)

NOC3L

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V260A	TCGA-D1-A103	UCEC	TCGA	MELFKD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.25
p.V260A	DO42312	UCEC	ICGC	MELFKD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.25
p.R276Q	TCGA-D1-A17Q	UCEC	TCGA	MELFKD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.1111
p.R276Q	DO41903	UCEC	ICGC	MELFKD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.1111
p.D268Y	TCGA-E6-A1M0	UCEC	TCGA	MELFKD	LIG_APCC_ABBA_1	263:268	Mutation altering degron motif	0.7325
p.D268Y	DO43682	UCEC	ICGC	MELFKD	LIG_APCC_ABBA_1	263:268	Mutation altering degron motif	0.7325
p.R255Q	DO233867	GACA	ICGC	MELFKD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.1111
p.R255Q	DO33084	PACA	ICGC	MELFKD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.1111
p.Y273F	DO23444	LINC	ICGC	MELFKD	LIG_APCC_ABBA_1	263:268	Mutation blocking phosphorylation signal	0.6389
p.P271S	DO220876	MELA	ICGC	MELFKD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.25
p.E270K	DO41235	UCEC	ICGC	MELFKD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc