DegronMD

Uniprot ID: Q8WTT2

Source protein: Nucleolar complex protein 3 homolog

Source gene: NOC3L

Class: LIG_APCC_ABBA_1

Location: 263:268

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6117

ASA_SCORE: 52.8667

COIL: 0.2653

CONS_SCORE: 0.6416

DSS_SCORE: 0.0593

HELIX: 0.721

FCONS_SCORE: 1.1163

RIG_SCORE: 0.887

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V260A	TCGA-D1-A103	UCEC	TCGA	MELFKD	LIG_APCC_ABBA_1	0.25
p.V260A	DO42312	UCEC	ICGC	MELFKD	LIG_APCC_ABBA_1	0.25
p.R276Q	TCGA-D1-A17Q	UCEC	TCGA	MELFKD	LIG_APCC_ABBA_1	0.1111
p.R276Q	DO41903	UCEC	ICGC	MELFKD	LIG_APCC_ABBA_1	0.1111
p.D268Y	TCGA-E6-A1M0	UCEC	TCGA	MELFKD	LIG_APCC_ABBA_1	0.7325
p.D268Y	DO43682	UCEC	ICGC	MELFKD	LIG_APCC_ABBA_1	0.7325
p.R255Q	DO233867	GACA	ICGC	MELFKD	LIG_APCC_ABBA_1	0.1111
p.R255Q	DO33084	PACA	ICGC	MELFKD	LIG_APCC_ABBA_1	0.1111
p.Y273F	DO23444	LINC	ICGC	MELFKD	LIG_APCC_ABBA_1	0.6389
p.P271S	DO220876	MELA	ICGC	MELFKD	LIG_APCC_ABBA_1	0.25
p.E270K	DO41235	UCEC	ICGC	MELFKD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WTT2	Nucleolar complex protein 3 homolog	LIG_APCC_ABBA_1	263:268	MELFKD	APC,CDC20,FZR1	0.6117	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons