MZB1
UniProt ID: Q8WU39
Entrez ID: 51237
Protein name: Marginal zone B- and B1-cell-specific protein (Mesenteric estrogen-dependent adipose 7) (MEDA-7) (Plasma cell-induced resident endoplasmic reticulum protein) (Plasma cell-induced resident ER protein) (pERp1) (Proapoptotic caspase adapter protein)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulat...
FUNCTION: Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation. {ECO:0000250, ECO:0000269|PubMed:11350957, ECO:0000269|PubMed:21688198}.; FUNCTION: Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.
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GO - Biological processes (BP):
apoptotic process [GO:0006915]; integrin activation [GO:0033622]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of immunoglobulin production [GO:0002639]; regulation of B cell proliferation [GO:0030888]; regulation of cell population proliferation [GO:0042127...
apoptotic process [GO:0006915]; integrin activation [GO:0033622]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of immunoglobulin production [GO:0002639]; regulation of B cell proliferation [GO:0030888]; regulation of cell population proliferation [GO:0042127]; regulation of insulin receptor signaling pathway [GO:0046626]
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GO - Molecular function (MF):
...
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]...
cytoplasm [GO:0005737]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]
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MZB1
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Kaplan plot for MZB1 in
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*NOTE: the Kaplan plots were collected from OncoLnc