DegronMD

Uniprot ID: Q8WU39

Source protein: Marginal zone B- and B1-cell-specific protein

Source gene: MZB1

Class: DEG_APCC_DBOX_1

Location: 1:9

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7032

ASA_SCORE: 99.1333

COIL: 0.3628

CONS_SCORE: 0.3898

DSS_SCORE: 0.1367

HELIX: 0.6067

FCONS_SCORE: 1.1787

RIG_SCORE: 0.9132

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G11R	DO229224	THCA	ICGC	MRLSLPLLL	DEG_APCC_DBOX_1	0.2778
p.G19R	SIDM00282	Colorectal Carcinoma	GDSC	MRLSLPLLL	DEG_APCC_DBOX_1	0.0556
p.G19R	CW-2	large_intestine	COSMIC	MRLSLPLLL	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WU39	Marginal zone B- and B1-cell-specific protein	DEG_APCC_DBOX_1	1:9	MRLSLPLLL	APC,CDC20,FZR1	0.7032	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons