CEMIP
UniProt ID: Q8WUJ3
Entrez ID: 57214
Protein name: Cell migration-inducing and hyaluronan-binding protein (EC 3.2.1.35)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endo...
FUNCTION: Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing. {ECO:0000269|PubMed:23509262, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:24269685}.
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GO - Biological processes (BP):
hyaluronan biosynthetic process [GO:0030213]; hyaluronan catabolic process [GO:0030214]; positive regulation of cell migration [GO:0030335]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein kinase C activity [GO:1900020]; positive regulation of p...
hyaluronan biosynthetic process [GO:0030213]; hyaluronan catabolic process [GO:0030214]; positive regulation of cell migration [GO:0030335]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein kinase C activity [GO:1900020]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; sensory perception of sound [GO:0007605]
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GO - Molecular function (MF):
clathrin heavy chain binding [GO:0032050]; ER retention sequence binding [GO:0046923]; hyaluronic acid binding [GO:0005540]; hyalurononglucosaminidase activity [GO:0004415]...
clathrin heavy chain binding [GO:0032050]; ER retention sequence binding [GO:0046923]; hyaluronic acid binding [GO:0005540]; hyalurononglucosaminidase activity [GO:0004415]
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GO - Cellular component (CC):
clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; nucleus [GO:0005634]; plasma membrane [GO:0005886]...
clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; nucleus [GO:0005634]; plasma membrane [GO:0005886]
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CEMIP
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Kaplan plot for CEMIP in
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*NOTE: the Kaplan plots were collected from OncoLnc