DegronMD

Uniprot ID: Q8WUJ3

Source protein: Cell migration-inducing and hyaluronan-binding protein

Source gene: CEMIP

Class: DEG_APCC_DBOX_1

Location: 753:761

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7385

ASA_SCORE: 31.2667

COIL: 0.5817

CONS_SCORE: 0.644

DSS_SCORE: 0.4108

HELIX: 0.0974

FCONS_SCORE: 0.8739

RIG_SCORE: 0.7766

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H767Q	SIDM00637	B-Cell Non-Hodgkin's Lymphoma	GDSC	KRPFLSIIS	DEG_APCC_DBOX_1	0.1667
p.H767Q	MC116	haematopoietic_and_lymphoid_tissue	COSMIC	KRPFLSIIS	DEG_APCC_DBOX_1	0.1667
p.D771N	SIDM01491	Colorectal Carcinoma	GDSC	KRPFLSIIS	DEG_APCC_DBOX_1	0.0556
p.A770V	SIDM01662	Plasma Cell Myeloma	GDSC	KRPFLSIIS	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WUJ3	Cell migration-inducing and hyaluronan-binding protein	DEG_APCC_DBOX_1	753:761	KRPFLSIIS	APC,CDC20,FZR1	0.7385	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons