SLC20A1
UniProt ID: Q8WUM9
Entrez ID: 6574
Protein name: Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extrac...
FUNCTION: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. {ECO:0000269|PubMed:11009570, ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:7966619, ECO:0000269|PubMed:8041748}.; FUNCTION: (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO:0000269|PubMed:12097582, ECO:0000269|PubMed:1309898, ECO:0000269|PubMed:2078500}.
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GO - Biological processes (BP):
biomineral tissue development [GO:0031214]; ion transport [GO:0006811]; phosphate-containing compound metabolic process [GO:0006796]; phosphate ion transmembrane transport [GO:0035435]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]...
biomineral tissue development [GO:0031214]; ion transport [GO:0006811]; phosphate-containing compound metabolic process [GO:0006796]; phosphate ion transmembrane transport [GO:0035435]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]
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GO - Molecular function (MF):
high-affinity inorganic phosphate:sodium symporter activity [GO:0005316]; inorganic phosphate transmembrane transporter activity [GO:0005315]; signaling receptor activity [GO:0038023]; sodium:phosphate symporter activity [GO:0005436]...
high-affinity inorganic phosphate:sodium symporter activity [GO:0005316]; inorganic phosphate transmembrane transporter activity [GO:0005315]; signaling receptor activity [GO:0038023]; sodium:phosphate symporter activity [GO:0005436]
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GO - Cellular component (CC):
integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]...
integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]
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SLC20A1
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Kaplan plot for SLC20A1 in
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*NOTE: the Kaplan plots were collected from OncoLnc