DegronMD

Uniprot ID: Q8WUM9

Source protein: Sodium-dependent phosphate transporter 1

Source gene: SLC20A1

Class: DEG_APCC_DBOX_1

Location: 329:337

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9818

ASA_SCORE: 91.4889

COIL: 0.7282

CONS_SCORE: 0.1978

DSS_SCORE: 0.5657

HELIX: 0.2154

FCONS_SCORE: 1.0237

RIG_SCORE: 0.7399

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D345Y	TCGA-SY-A9G5	BLCA	TCGA	ERERLPSVD	DEG_APCC_DBOX_1	0.1111
p.D345Y	DO51906	BLCA	ICGC	ERERLPSVD	DEG_APCC_DBOX_1	0.1111
p.T342N	TCGA-UF-A7JT	HNSC	TCGA	ERERLPSVD	DEG_APCC_DBOX_1	0.1944
p.T342N	DO219090	HNSC	ICGC	ERERLPSVD	DEG_APCC_DBOX_1	0.1944
p.R332G	TCGA-X7-A8D8	THYM	TCGA	ERERLPSVD	DEG_APCC_DBOX_1	0.6457
p.L324F	DO227982	COCA	ICGC	ERERLPSVD	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WUM9	Sodium-dependent phosphate transporter 1	DEG_APCC_DBOX_1	329:337	ERERLPSVD	APC,CDC20,FZR1	0.9818	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons