DegronMD - Q8WUQ7(CACTIN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D89N	TCGA-2H-A9GF	ESCA	TCGA	DSGEEQS	DEG_SCF_TRCP1_1	89:95	Mutation altering degron motif	0.6932
p.G84V	TCGA-BR-4368	STAD	TCGA	DSGEEQS	DEG_SCF_TRCP1_1	89:95	Mutation rewiring degron network	0.1944
p.G84V	DO38715	STAD	ICGC	DSGEEQS	DEG_SCF_TRCP1_1	89:95	Mutation rewiring degron network	0.1944
p.S81L	TCGA-E7-A7XN	BLCA	TCGA	DSGEEQS	DEG_SCF_TRCP1_1	89:95	Mutation rewiring degron network	0.1111
p.S81L	DO51878	BLCA	ICGC	DSGEEQS	DEG_SCF_TRCP1_1	89:95	Mutation rewiring degron network	0.1111
p.R96Q	TCGA-IB-7651	PAAD	TCGA	DSGEEQS	DEG_SCF_TRCP1_1	89:95	Mutation rewiring degron network	0.3056
p.R96Q	DO46657	PAAD	ICGC	DSGEEQS	DEG_SCF_TRCP1_1	89:95	Mutation rewiring degron network	0.3056
p.R103Q	DO222427	BTCA	ICGC	DSGEEQS	DEG_SCF_TRCP1_1	89:95	Mutation rewiring degron network	0.1111
p.S86C	DO222830	BTCA	ICGC	DSGEEQS	DEG_SCF_TRCP1_1	89:95	Mutation blocking phosphorylation signal	0.6944
p.S88L	DO50374	ESAD	ICGC	DSGEEQS	DEG_SCF_TRCP1_1	89:95	Mutation blocking phosphorylation signal	0.75
p.R105C	DO233652	GACA	ICGC	DSGEEQS	DEG_SCF_TRCP1_1	89:95	Mutation rewiring degron network	0.0556
p.R105H	DO233624	GACA	ICGC	DSGEEQS	DEG_SCF_TRCP1_1	89:95	Mutation rewiring degron network	0.0556
p.R101S	DO228948	LICA	ICGC	DSGEEQS	DEG_SCF_TRCP1_1	89:95	Mutation rewiring degron network	0.1667
p.R104Q	DO50970	LICA	ICGC	DSGEEQS	DEG_SCF_TRCP1_1	89:95	Mutation rewiring degron network	0.0833
p.R102W	SIDM01004	Chronic Myelogenous Leukemia	GDSC	DSGEEQS	DEG_SCF_TRCP1_1	89:95	Mutation rewiring degron network	0.1389
p.R102W	ACH-000983	Leukemia	CCLE	DSGEEQS	DEG_SCF_TRCP1_1	89:95	Mutation rewiring degron network	0.1389
p.R102W	KCL-22	haematopoietic and lymphoid tissue	COSMIC	DSGEEQS	DEG_SCF_TRCP1_1	89:95	Mutation rewiring degron network	0.1389
p.A100T	ACH-000455	Brain Cancer	CCLE	DSGEEQS	DEG_SCF_TRCP1_1	89:95	Mutation rewiring degron network	0.1944

Kaplan plot for CACTIN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CACTIN

UniProt ID: Q8WUQ7

Entrez ID: 58509

Protein name: Cactin (Renal carcinoma antigen NY-REN-24)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CACTIN in