DegronMD

Uniprot ID: Q8WUQ7

Source protein: Cactin

Source gene: CACTIN

Class: DEG_SCF_TRCP1_1

Location: 89:95

E3 ligase: BTRC

DEGRON score: 0.7746

ASA_SCORE: 110.6

COIL: 0.9371

CONS_SCORE: 0.2787

DSS_SCORE: 0.7209

HELIX: 0.0633

FCONS_SCORE: 0.8941

RIG_SCORE: 0.5599

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D89N	TCGA-2H-A9GF	ESCA	TCGA	DSGEEQS	DEG_SCF_TRCP1_1	0.6932
p.G84V	TCGA-BR-4368	STAD	TCGA	DSGEEQS	DEG_SCF_TRCP1_1	0.1944
p.G84V	DO38715	STAD	ICGC	DSGEEQS	DEG_SCF_TRCP1_1	0.1944
p.S81L	TCGA-E7-A7XN	BLCA	TCGA	DSGEEQS	DEG_SCF_TRCP1_1	0.1111
p.S81L	DO51878	BLCA	ICGC	DSGEEQS	DEG_SCF_TRCP1_1	0.1111
p.R96Q	TCGA-IB-7651	PAAD	TCGA	DSGEEQS	DEG_SCF_TRCP1_1	0.3056
p.R96Q	DO46657	PAAD	ICGC	DSGEEQS	DEG_SCF_TRCP1_1	0.3056
p.R103Q	DO222427	BTCA	ICGC	DSGEEQS	DEG_SCF_TRCP1_1	0.1111
p.S86C	DO222830	BTCA	ICGC	DSGEEQS	DEG_SCF_TRCP1_1	0.6944
p.S88L	DO50374	ESAD	ICGC	DSGEEQS	DEG_SCF_TRCP1_1	0.75
p.R105C	DO233652	GACA	ICGC	DSGEEQS	DEG_SCF_TRCP1_1	0.0556
p.R105H	DO233624	GACA	ICGC	DSGEEQS	DEG_SCF_TRCP1_1	0.0556
p.R101S	DO228948	LICA	ICGC	DSGEEQS	DEG_SCF_TRCP1_1	0.1667
p.R104Q	DO50970	LICA	ICGC	DSGEEQS	DEG_SCF_TRCP1_1	0.0833
p.R102W	SIDM01004	Chronic Myelogenous Leukemia	GDSC	DSGEEQS	DEG_SCF_TRCP1_1	0.1389
p.R102W	ACH-000983	Leukemia	CCLE	DSGEEQS	DEG_SCF_TRCP1_1	0.1389
p.R102W	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	DSGEEQS	DEG_SCF_TRCP1_1	0.1389
p.A100T	ACH-000455	Brain Cancer	CCLE	DSGEEQS	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WUQ7	Cactin	DEG_SCF_TRCP1_1	89:95	DSGEEQS	BTRC	0.7746	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons