DegronMD - Q8WUS8(SDR42E1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E138A	TCGA-AJ-A3EL	UCEC	TCGA	LHLHPD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.1389
p.E138A	DO41542	UCEC	ICGC	LHLHPD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.1389
p.G136R	TCGA-D3-A2JO	SKCM	TCGA	LHLHPD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.0833
p.G136R	DO47619	SKCM	ICGC	LHLHPD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.0833
p.D150N	TCGA-D9-A6EC	SKCM	TCGA	LHLHPD	LIG_APCC_ABBA_1	145:150	Mutation altering degron motif	0.6932
p.D150N	DO50291	SKCM	ICGC	LHLHPD	LIG_APCC_ABBA_1	145:150	Mutation altering degron motif	0.6932
p.R154W	TCGA-DA-A1HY	SKCM	TCGA	LHLHPD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.2222
p.R154W	DO233267	GACA	ICGC	LHLHPD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.2222
p.R154W	DO222647	MELA	ICGC	LHLHPD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.2222
p.R154W	DO37409	SKCM	ICGC	LHLHPD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.2222
p.H151Y	TCGA-FW-A3R5	SKCM	TCGA	LHLHPD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.3056
p.H151Y	DO37406	SKCM	ICGC	LHLHPD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.3056
p.T155K	DO229034	LICA	ICGC	LHLHPD	LIG_APCC_ABBA_1	145:150	Mutation blocking phosphorylation signal	0.6389
p.P144T	DO229035	LICA	ICGC	LHLHPD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.3056
p.L147I	DO229041	LICA	ICGC	LHLHPD	LIG_APCC_ABBA_1	145:150	Mutation altering degron motif	0.6063
p.E160K	DO220882	MELA	ICGC	LHLHPD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.0556
p.Y142C	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	LHLHPD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.25
p.Y142C	ACH-000553	Lung Cancer	CCLE	LHLHPD	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.25

Kaplan plot for SDR42E1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SDR42E1

UniProt ID: Q8WUS8

Entrez ID: 93517

Protein name: Short-chain dehydrogenase/reductase family 42E member 1 (EC 1.1.1.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SDR42E1 in