DegronMD

Uniprot ID: Q8WUS8

Source protein: Short-chain dehydrogenase/reductase family 42E member 1

Source gene: SDR42E1

Class: LIG_APCC_ABBA_1

Location: 145:150

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9776

ASA_SCORE: 71.9167

COIL: 0.8345

CONS_SCORE: 0.3276

DSS_SCORE: 0.3331

HELIX: 0.1572

FCONS_SCORE: 0.6106

RIG_SCORE: 0.742

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D150N	TCGA-D9-A6EC	SKCM	TCGA	LHLHPD	LIG_APCC_ABBA_1	0.6932
p.D150N	DO50291	SKCM	ICGC	LHLHPD	LIG_APCC_ABBA_1	0.6932
p.T155K	DO229034	LICA	ICGC	LHLHPD	LIG_APCC_ABBA_1	0.6389
p.L147I	DO229041	LICA	ICGC	LHLHPD	LIG_APCC_ABBA_1	0.6063
p.H151Y	TCGA-FW-A3R5	SKCM	TCGA	LHLHPD	LIG_APCC_ABBA_1	0.3056
p.H151Y	DO37406	SKCM	ICGC	LHLHPD	LIG_APCC_ABBA_1	0.3056
p.P144T	DO229035	LICA	ICGC	LHLHPD	LIG_APCC_ABBA_1	0.3056
p.Y142C	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	LHLHPD	LIG_APCC_ABBA_1	0.25
p.Y142C	ACH-000553	Lung Cancer	CCLE	LHLHPD	LIG_APCC_ABBA_1	0.25
p.R154W	TCGA-DA-A1HY	SKCM	TCGA	LHLHPD	LIG_APCC_ABBA_1	0.2222
p.R154W	DO233267	GACA	ICGC	LHLHPD	LIG_APCC_ABBA_1	0.2222
p.R154W	DO222647	MELA	ICGC	LHLHPD	LIG_APCC_ABBA_1	0.2222
p.R154W	DO37409	SKCM	ICGC	LHLHPD	LIG_APCC_ABBA_1	0.2222
p.E138A	TCGA-AJ-A3EL	UCEC	TCGA	LHLHPD	LIG_APCC_ABBA_1	0.1389
p.E138A	DO41542	UCEC	ICGC	LHLHPD	LIG_APCC_ABBA_1	0.1389
p.G136R	TCGA-D3-A2JO	SKCM	TCGA	LHLHPD	LIG_APCC_ABBA_1	0.0833
p.G136R	DO47619	SKCM	ICGC	LHLHPD	LIG_APCC_ABBA_1	0.0833
p.E160K	DO220882	MELA	ICGC	LHLHPD	LIG_APCC_ABBA_1	0.0556

Showing 1 to 18 of 18 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WUS8	Short-chain dehydrogenase/reductase family 42E member 1	LIG_APCC_ABBA_1	145:150	LHLHPD	APC,CDC20,FZR1	0.9776	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons