DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LHLHPD
Uniprot ID:
Q8WUS8
Source protein:
Short-chain dehydrogenase/reductase family 42E member 1
Source gene:
SDR42E1
Class:
LIG_APCC_ABBA_1
Location:
145:150
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9776
ASA_SCORE:
71.9167
COIL:
0.8345
CONS_SCORE:
0.3276
DSS_SCORE:
0.3331
HELIX:
0.1572
FCONS_SCORE:
0.6106
RIG_SCORE:
0.742
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E138A
TCGA-AJ-A3EL
UCEC
TCGA
LHLHPD
LIG_APCC_ABBA_1
0.1389
p.E138A
DO41542
UCEC
ICGC
LHLHPD
LIG_APCC_ABBA_1
0.1389
p.G136R
TCGA-D3-A2JO
SKCM
TCGA
LHLHPD
LIG_APCC_ABBA_1
0.0833
p.G136R
DO47619
SKCM
ICGC
LHLHPD
LIG_APCC_ABBA_1
0.0833
p.D150N
TCGA-D9-A6EC
SKCM
TCGA
LHLHPD
LIG_APCC_ABBA_1
0.6932
p.D150N
DO50291
SKCM
ICGC
LHLHPD
LIG_APCC_ABBA_1
0.6932
p.R154W
TCGA-DA-A1HY
SKCM
TCGA
LHLHPD
LIG_APCC_ABBA_1
0.2222
p.R154W
DO233267
GACA
ICGC
LHLHPD
LIG_APCC_ABBA_1
0.2222
p.R154W
DO222647
MELA
ICGC
LHLHPD
LIG_APCC_ABBA_1
0.2222
p.R154W
DO37409
SKCM
ICGC
LHLHPD
LIG_APCC_ABBA_1
0.2222
p.H151Y
TCGA-FW-A3R5
SKCM
TCGA
LHLHPD
LIG_APCC_ABBA_1
0.3056
p.H151Y
DO37406
SKCM
ICGC
LHLHPD
LIG_APCC_ABBA_1
0.3056
p.T155K
DO229034
LICA
ICGC
LHLHPD
LIG_APCC_ABBA_1
0.6389
p.P144T
DO229035
LICA
ICGC
LHLHPD
LIG_APCC_ABBA_1
0.3056
p.L147I
DO229041
LICA
ICGC
LHLHPD
LIG_APCC_ABBA_1
0.6063
p.E160K
DO220882
MELA
ICGC
LHLHPD
LIG_APCC_ABBA_1
0.0556
p.Y142C
SIDM01767
Squamous Cell Lung Carcinoma
GDSC
LHLHPD
LIG_APCC_ABBA_1
0.25
p.Y142C
ACH-000553
Lung Cancer
CCLE
LHLHPD
LIG_APCC_ABBA_1
0.25
Drug responses associated with SDR42E1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LHLHPD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8WUS8
Short-chain dehydrogenase/reductase family 42E member 1
LIG_APCC_ABBA_1
145:150
LHLHPD
APC,CDC20,FZR1
0.9776
More...