DegronMD - Q8WV41(SNX33)

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y70S	TCGA-13-0791	OV	TCGA	NHADYSSSP	CBL_PTK	66:74	Mutation altering degron motif	0.8231
p.Y70S	DO32688	OV	ICGC	NHADYSSSP	CBL_PTK	66:74	Mutation altering degron motif	0.8231
p.V59I	TCGA-34-5232	LUSC	TCGA	NHADYSSSP	CBL_PTK	66:74	Mutation rewiring degron network	0.1389
p.V59I	DO27168	LUSC	ICGC	NHADYSSSP	CBL_PTK	66:74	Mutation rewiring degron network	0.1389
p.V59I	ACH-001843	Bile Duct Cancer	CCLE	NHADYSSSP	CBL_PTK	66:74	Mutation rewiring degron network	0.1389
p.G79R	TCGA-EO-A22U	UCEC	TCGA	NHADYSSSP	CBL_PTK	66:74	Mutation rewiring degron network	0.1944
p.G79R	DO43755	UCEC	ICGC	NHADYSSSP	CBL_PTK	66:74	Mutation rewiring degron network	0.1944
p.E57K	TCGA-YC-A89H	BLCA	TCGA	NHADYSSSP	CBL_PTK	66:74	Mutation rewiring degron network	0.0833
p.E57K	DO51948	BLCA	ICGC	NHADYSSSP	CBL_PTK	66:74	Mutation rewiring degron network	0.0833
p.S72R	DO223051	ESCA	ICGC	NHADYSSSP	CBL_PTK	66:74	Mutation altering degron motif	0.7427
p.P74S	SIDM00324	Neuroblastoma	GDSC	NHADYSSSP	CBL_PTK	66:74	Mutation altering degron motif	0.6752
p.P74S	ACH-001674	Neuroblastoma	CCLE	NHADYSSSP	CBL_PTK	66:74	Mutation altering degron motif	0.6752
p.P74S	TGW	autonomic ganglia	COSMIC	NHADYSSSP	CBL_PTK	66:74	Mutation altering degron motif	0.6752
p.V59L	ACH-000629	Brain Cancer	CCLE	NHADYSSSP	CBL_PTK	66:74	Mutation rewiring degron network	0.1389
p.S77F	ACH-002005	Skin Cancer	CCLE	NHADYSSSP	CBL_PTK	66:74	Mutation blocking phosphorylation signal	0.6944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons