DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
NHADYSSSP
Uniprot ID:
Q8WV41
Source protein:
Sorting nexin-33
Source gene:
SNX33
Class:
CBL_PTK
Location:
66:74
E3 ligase:
CBL
DEGRON score:
0.9981
ASA_SCORE:
72.6889
COIL:
0.8549
CONS_SCORE:
0.373
DSS_SCORE:
0.4888
HELIX:
0.0754
FCONS_SCORE:
0.9766
RIG_SCORE:
0.665
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Y70S
TCGA-13-0791
OV
TCGA
NHADYSSSP
CBL_PTK
0.8231
p.Y70S
DO32688
OV
ICGC
NHADYSSSP
CBL_PTK
0.8231
p.V59I
TCGA-34-5232
LUSC
TCGA
NHADYSSSP
CBL_PTK
0.1389
p.V59I
DO27168
LUSC
ICGC
NHADYSSSP
CBL_PTK
0.1389
p.V59I
ACH-001843
Bile Duct Cancer
CCLE
NHADYSSSP
CBL_PTK
0.1389
p.G79R
TCGA-EO-A22U
UCEC
TCGA
NHADYSSSP
CBL_PTK
0.1944
p.G79R
DO43755
UCEC
ICGC
NHADYSSSP
CBL_PTK
0.1944
p.E57K
TCGA-YC-A89H
BLCA
TCGA
NHADYSSSP
CBL_PTK
0.0833
p.E57K
DO51948
BLCA
ICGC
NHADYSSSP
CBL_PTK
0.0833
p.S72R
DO223051
ESCA
ICGC
NHADYSSSP
CBL_PTK
0.7427
p.P74S
SIDM00324
Neuroblastoma
GDSC
NHADYSSSP
CBL_PTK
0.6752
p.P74S
ACH-001674
Neuroblastoma
CCLE
NHADYSSSP
CBL_PTK
0.6752
p.P74S
TGW
autonomic_ganglia
COSMIC
NHADYSSSP
CBL_PTK
0.6752
p.V59L
ACH-000629
Brain Cancer
CCLE
NHADYSSSP
CBL_PTK
0.1389
p.S77F
ACH-002005
Skin Cancer
CCLE
NHADYSSSP
CBL_PTK
0.6944
Drug responses associated with SNX33 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NHADYSSSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8WV41
Sorting nexin-33
CBL_PTK
66:74
NHADYSSSP
CBL
0.9981
More...
