DegronMD - Q8WVB6(CHTF18)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S125C	TCGA-19-2620	GBM	TCGA	ITPPPS	DEG_SCF_FBW7_1	130:135	Mutation rewiring degron network	0.1944
p.L139I	TCGA-AA-3947	COAD	TCGA	ITPPPS	DEG_SCF_FBW7_1	130:135	Mutation rewiring degron network	0.2222
p.P133L	TCGA-AJ-A8CT	UCEC	TCGA	ITPPPS	DEG_SCF_FBW7_1	130:135	Mutation altering degron motif	0.6471
p.E141D	TCGA-DX-A6YV	SARC	TCGA	ITPPPS	DEG_SCF_FBW7_1	130:135	Mutation rewiring degron network	0.1667
p.V135F	DO44465	KIRP	ICGC	ITPPPS	DEG_SCF_FBW7_1	130:135	Mutation altering degron motif	0.7068
p.R139K	DO222731	MELA	ICGC	ITPPPS	DEG_SCF_FBW7_1	130:135	Mutation rewiring degron network	0.2222
p.R139K	DO37750	SKCM	ICGC	ITPPPS	DEG_SCF_FBW7_1	130:135	Mutation rewiring degron network	0.2222
p.E144G	DO233298	NACA	ICGC	ITPPPS	DEG_SCF_FBW7_1	130:135	Mutation rewiring degron network	0.0833
p.Q130P	DO218900	SKCA	ICGC	ITPPPS	DEG_SCF_FBW7_1	130:135	Mutation altering degron motif	0.7035
p.S125F	SIDM00011	Melanoma	GDSC	ITPPPS	DEG_SCF_FBW7_1	130:135	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons