DegronMD

Uniprot ID: Q8WVB6

Source protein: Chromosome transmission fidelity protein 18 homolog

Source gene: CHTF18

Class: DEG_SCF_FBW7_1

Location: 130:135

E3 ligase: FBXW7

DEGRON score: 0.9963

ASA_SCORE: 65

COIL: 0.9645

CONS_SCORE: 0.255

DSS_SCORE: 0.8332

HELIX: 0.0137

FCONS_SCORE: 1.1881

RIG_SCORE: 0.5736

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S125C	TCGA-19-2620	GBM	TCGA	ITPPPS	DEG_SCF_FBW7_1	0.1944
p.L139I	TCGA-AA-3947	COAD	TCGA	ITPPPS	DEG_SCF_FBW7_1	0.2222
p.P133L	TCGA-AJ-A8CT	UCEC	TCGA	ITPPPS	DEG_SCF_FBW7_1	0.6471
p.E141D	TCGA-DX-A6YV	SARC	TCGA	ITPPPS	DEG_SCF_FBW7_1	0.1667
p.V135F	DO44465	KIRP	ICGC	ITPPPS	DEG_SCF_FBW7_1	0.7068
p.R139K	DO222731	MELA	ICGC	ITPPPS	DEG_SCF_FBW7_1	0.2222
p.R139K	DO37750	SKCM	ICGC	ITPPPS	DEG_SCF_FBW7_1	0.2222
p.E144G	DO233298	NACA	ICGC	ITPPPS	DEG_SCF_FBW7_1	0.0833
p.Q130P	DO218900	SKCA	ICGC	ITPPPS	DEG_SCF_FBW7_1	0.7035
p.S125F	SIDM00011	Melanoma	GDSC	ITPPPS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WVB6	Chromosome transmission fidelity protein 18 homolog	DEG_SCF_FBW7_1	130:135	ITPPPS	FBXW7	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons