DegronMD - Q8WVC6(DCAKD)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A142T	TCGA-AX-A05S	UCEC	TCGA	VVVYCD	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.1667
p.A142T	DO43218	UCEC	ICGC	VVVYCD	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.1667
p.K125E	TCGA-AX-A1C4	UCEC	TCGA	VVVYCD	LIG_APCC_ABBA_1	131:136	Mutation substituting flanking lysine	0.2778
p.K125E	DO42480	UCEC	ICGC	VVVYCD	LIG_APCC_ABBA_1	131:136	Mutation substituting flanking lysine	0.2778
p.R137Q	TCGA-EO-A22U	UCEC	TCGA	VVVYCD	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.3056
p.R137Q	DO43755	UCEC	ICGC	VVVYCD	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.3056
p.L124I	DO229019	LICA	ICGC	VVVYCD	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.1389
p.E123K	DO220906	MELA	ICGC	VVVYCD	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.1111
p.R137W	SIDM01090	Colorectal Carcinoma	GDSC	VVVYCD	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.3056
p.H129P	SIDM00599	Osteosarcoma	GDSC	VVVYCD	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.2778
p.H129P	ACH-001526	Bone Cancer	CCLE	VVVYCD	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.2778
p.H129P	HuO9	bone	COSMIC	VVVYCD	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.2778
p.L124F	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VVVYCD	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.1389
p.L124F	ACH-001127	Leukemia	CCLE	VVVYCD	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons