DegronMD

Uniprot ID: Q8WVC6

Source protein: Dephospho-CoA kinase domain-containing protein

Source gene: DCAKD

Class: LIG_APCC_ABBA_1

Location: 131:136

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6133

ASA_SCORE: 28.2333

COIL: 0.3947

CONS_SCORE: 0.5554

DSS_SCORE: 0.0562

HELIX: 0.0048

FCONS_SCORE: 1.1914

RIG_SCORE: 0.9704

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A142T	TCGA-AX-A05S	UCEC	TCGA	VVVYCD	LIG_APCC_ABBA_1	0.1667
p.A142T	DO43218	UCEC	ICGC	VVVYCD	LIG_APCC_ABBA_1	0.1667
p.K125E	TCGA-AX-A1C4	UCEC	TCGA	VVVYCD	LIG_APCC_ABBA_1	0.2778
p.K125E	DO42480	UCEC	ICGC	VVVYCD	LIG_APCC_ABBA_1	0.2778
p.R137Q	TCGA-EO-A22U	UCEC	TCGA	VVVYCD	LIG_APCC_ABBA_1	0.3056
p.R137Q	DO43755	UCEC	ICGC	VVVYCD	LIG_APCC_ABBA_1	0.3056
p.L124I	DO229019	LICA	ICGC	VVVYCD	LIG_APCC_ABBA_1	0.1389
p.E123K	DO220906	MELA	ICGC	VVVYCD	LIG_APCC_ABBA_1	0.1111
p.R137W	SIDM01090	Colorectal Carcinoma	GDSC	VVVYCD	LIG_APCC_ABBA_1	0.3056
p.H129P	SIDM00599	Osteosarcoma	GDSC	VVVYCD	LIG_APCC_ABBA_1	0.2778
p.H129P	ACH-001526	Bone Cancer	CCLE	VVVYCD	LIG_APCC_ABBA_1	0.2778
p.H129P	HuO9	bone	COSMIC	VVVYCD	LIG_APCC_ABBA_1	0.2778
p.L124F	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VVVYCD	LIG_APCC_ABBA_1	0.1389
p.L124F	ACH-001127	Leukemia	CCLE	VVVYCD	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WVC6	Dephospho-CoA kinase domain-containing protein	LIG_APCC_ABBA_1	131:136	VVVYCD	APC,CDC20,FZR1	0.6133	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons