DegronMD - Q8WVF1(OSCP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N279I	TCGA-18-3421	LUSC	TCGA	IAPNPLAKEELNF	DEG_ODPH_VHL_1	286:298	Mutation rewiring degron network	0.1389
p.E284V	TCGA-68-7757	LUSC	TCGA	IAPNPLAKEELNF	DEG_ODPH_VHL_1	286:298	Mutation rewiring degron network	0.2778
p.L289M	TCGA-AA-A022	COAD	TCGA	IAPNPLAKEELNF	DEG_ODPH_VHL_1	286:298	Mutation altering degron motif	0.711
p.I298T	TCGA-BG-A2L7	UCEC	TCGA	IAPNPLAKEELNF	DEG_ODPH_VHL_1	286:298	Mutation altering degron motif	0.7078
p.E303Q	DO6320	CESC	ICGC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	286:298	Mutation rewiring degron network	0.1944
p.R300W	DO50091	COAD	ICGC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	286:298	Mutation rewiring degron network	0.2778
p.Y287S	DO233831	GACA	ICGC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	286:298	Mutation altering degron motif	0.712
p.P282Q	DO228971	LICA	ICGC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	286:298	Mutation rewiring degron network	0.2222
p.P282Q	DO229037	LICA	ICGC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	286:298	Mutation rewiring degron network	0.2222
p.N291K	DO23705	LUAD	ICGC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	286:298	Mutation altering degron motif	0.6918
p.I307M	DO29438	OV	ICGC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	286:298	Mutation rewiring degron network	0.0833
p.G305W	SIDM00789	Colorectal Carcinoma	GDSC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	286:298	Mutation rewiring degron network	0.1389
p.G305W	HCT-15	large intestine	COSMIC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	286:298	Mutation rewiring degron network	0.1389
p.F298L	SIDM00193	Colorectal Carcinoma	GDSC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	286:298	Mutation altering degron motif	0.587
p.F298L	SNU-81	large intestine	COSMIC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	286:298	Mutation altering degron motif	0.587
p.F288L	SNU-81	large intestine	COSMIC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	286:298	Mutation altering degron motif	0.6981
p.G295W	HCT-15	large intestine	COSMIC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	286:298	Mutation altering degron motif	0.7825
p.T295P	PANC-02-03	pancreas	COSMIC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	286:298	Mutation altering degron motif	0.7031

Kaplan plot for OSCP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OSCP1

UniProt ID: Q8WVF1

Entrez ID: 127700

Protein name: Protein OSCP1 (hOSCP1) (Organic solute transport protein 1) (Oxidored-nitro domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OSCP1 in