DegronMD

Uniprot ID: Q8WVF1

Source protein: Protein OSCP1

Source gene: OSCP1

Class: DEG_ODPH_VHL_1

Location: 286:298

E3 ligase: VHL

DEGRON score: 0.6415

ASA_SCORE: 66.4154

COIL: 0.3754

CONS_SCORE: 0.4462

DSS_SCORE: 0.3518

HELIX: 0.6119

FCONS_SCORE: 1.1076

RIG_SCORE: 0.7861

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N279I	TCGA-18-3421	LUSC	TCGA	IAPNPLAKEELNF	DEG_ODPH_VHL_1	0.1389
p.E284V	TCGA-68-7757	LUSC	TCGA	IAPNPLAKEELNF	DEG_ODPH_VHL_1	0.2778
p.L289M	TCGA-AA-A022	COAD	TCGA	IAPNPLAKEELNF	DEG_ODPH_VHL_1	0.711
p.I298T	TCGA-BG-A2L7	UCEC	TCGA	IAPNPLAKEELNF	DEG_ODPH_VHL_1	0.7078
p.E303Q	DO6320	CESC	ICGC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	0.1944
p.R300W	DO50091	COAD	ICGC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	0.2778
p.Y287S	DO233831	GACA	ICGC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	0.712
p.P282Q	DO228971	LICA	ICGC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	0.2222
p.P282Q	DO229037	LICA	ICGC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	0.2222
p.N291K	DO23705	LUAD	ICGC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	0.6918
p.I307M	DO29438	OV	ICGC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	0.0833
p.G305W	SIDM00789	Colorectal Carcinoma	GDSC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	0.1389
p.G305W	HCT-15	large_intestine	COSMIC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	0.1389
p.F298L	SIDM00193	Colorectal Carcinoma	GDSC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	0.587
p.F298L	SNU-81	large_intestine	COSMIC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	0.587
p.F288L	SNU-81	large_intestine	COSMIC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	0.6981
p.G295W	HCT-15	large_intestine	COSMIC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	0.7825
p.T295P	PANC-02-03	pancreas	COSMIC	IAPNPLAKEELNF	DEG_ODPH_VHL_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WVF1	Protein OSCP1	DEG_ODPH_VHL_1	286:298	IAPNPLAKEELNF	VHL	0.6415	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons