DYNC2I1
UniProt ID: Q8WVS4
Entrez ID: 55112
Protein name: Cytoplasmic dynein 2 intermediate chain 1 (Dynein 2 intermediate chain 1) (WD repeat-containing protein 60)
External links: UniprotKB HGNC RefSeq COSMIC
Please click HERE
for better display.
FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system (PubMed:239104...
FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system (PubMed:23910462, PubMed:25205765, PubMed:31451806, PubMed:29742051). DYNC2I1 plays a major role in retrograde ciliary protein trafficking in cilia and flagella (PubMed:29742051, PubMed:30320547, PubMed:30649997). Requires also to maintain a functional transition zone (PubMed:30320547). {ECO:0000269|PubMed:23910462, ECO:0000269|PubMed:25205765, ECO:0000269|PubMed:29742051, ECO:0000269|PubMed:30320547, ECO:0000269|PubMed:30649997, ECO:0000269|PubMed:31451806}.
View more >>
GO - Biological processes (BP):
cilium assembly [GO:0060271]; embryonic skeletal system morphogenesis [GO:0048704]; intraciliary retrograde transport [GO:0035721]; intraciliary transport [GO:0042073]; microtubule-based movement [GO:0007018]...
cilium assembly [GO:0060271]; embryonic skeletal system morphogenesis [GO:0048704]; intraciliary retrograde transport [GO:0035721]; intraciliary transport [GO:0042073]; microtubule-based movement [GO:0007018]
View more >>
GO - Molecular function (MF):
dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]...
dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]
View more >>
GO - Cellular component (CC):
centrosome [GO:0005813]; ciliary base [GO:0097546]; ciliary plasm [GO:0097014]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasmic dynein complex [GO:0005868]; extracellular space [GO:0005615]; pericentriolar material [GO:0000242]...
centrosome [GO:0005813]; ciliary base [GO:0097546]; ciliary plasm [GO:0097014]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasmic dynein complex [GO:0005868]; extracellular space [GO:0005615]; pericentriolar material [GO:0000242]
View more >>
DYNC2I1
Control panel
Show dataset:
Show Degron:
All sites
Degron
Degron
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for DYNC2I1 in
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc