DegronMD

Uniprot ID: Q8WVS4

Source protein: Cytoplasmic dynein 2 intermediate chain 1

Source gene: DYNC2I1

Class: DEG_APCC_DBOX_1

Location: 18:26

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7405

ASA_SCORE: 94.2333

COIL: 0.2537

CONS_SCORE: 0.3172

DSS_SCORE: 0.4859

HELIX: 0.7501

FCONS_SCORE: 0.9952

RIG_SCORE: 0.7842

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K31N	SIDM00216	Colorectal Carcinoma	GDSC	LRKHLWAIQ	DEG_APCC_DBOX_1	0.3056
p.R34G	SIDM00878	Breast Carcinoma	GDSC	LRKHLWAIQ	DEG_APCC_DBOX_1	0.1111
p.K20Q	SIDM01611	Endometrial Carcinoma	GDSC	LRKHLWAIQ	DEG_APCC_DBOX_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WVS4	Cytoplasmic dynein 2 intermediate chain 1	DEG_APCC_DBOX_1	18:26	LRKHLWAIQ	APC,CDC20,FZR1	0.7405	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons