DegronMD - Q8WVV4(POF1B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R72W	TCGA-06-1804	GBM	TCGA	SREVLSPLK	DEG_APCC_DBOX_1	71:79	Mutation altering degron motif	0.8634
p.R72W	DO12304	GBM	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	71:79	Mutation altering degron motif	0.8634
p.L87V	TCGA-A5-A1OF	UCEC	TCGA	SREVLSPLK	DEG_APCC_DBOX_1	71:79	Mutation rewiring degron network	0.1111
p.L87V	DO42568	UCEC	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	71:79	Mutation rewiring degron network	0.1111
p.N70D	TCGA-AJ-A3EL	UCEC	TCGA	SREVLSPLK	DEG_APCC_DBOX_1	71:79	Mutation rewiring degron network	0.3056
p.N70D	DO41542	UCEC	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	71:79	Mutation rewiring degron network	0.3056
p.P77S	TCGA-BF-A3DM	SKCM	TCGA	SREVLSPLK	DEG_APCC_DBOX_1	71:79	Mutation altering degron motif	0.5641
p.P77S	DO48667	SKCM	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	71:79	Mutation altering degron motif	0.5641
p.S83T	TCGA-D3-A8GI	SKCM	TCGA	SREVLSPLK	DEG_APCC_DBOX_1	71:79	Mutation rewiring degron network	0.2222
p.S83T	DO50284	SKCM	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	71:79	Mutation rewiring degron network	0.2222
p.R72L	TCGA-ER-A19P	SKCM	TCGA	SREVLSPLK	DEG_APCC_DBOX_1	71:79	Mutation altering degron motif	0.8428
p.R72L	DO47623	SKCM	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	71:79	Mutation altering degron motif	0.8428
p.T81I	TCGA-FS-A4F4	SKCM	TCGA	SREVLSPLK	DEG_APCC_DBOX_1	71:79	Mutation rewiring degron network	0.2778
p.T81I	DO37926	SKCM	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	71:79	Mutation rewiring degron network	0.2778
p.L75I	DO45229	LIRI	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	71:79	Mutation altering degron motif	0.7174
p.F69L	DO27817	MALY	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	71:79	Mutation rewiring degron network	0.2778
p.V88I	DO221123	MALY	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	71:79	Mutation rewiring degron network	0.0833
p.E73K	DO222824	MELA	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	71:79	Mutation altering degron motif	0.591
p.S76F	DO218900	SKCA	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	71:79	Mutation altering degron motif	0.7982
p.Q64R	SIDM01173	Rhabdomyosarcoma	GDSC	SREVLSPLK	DEG_APCC_DBOX_1	71:79	Mutation rewiring degron network	0.1389

Kaplan plot for POF1B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POF1B

UniProt ID: Q8WVV4

Entrez ID: 79983

Protein name: Protein POF1B (Premature ovarian failure protein 1B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for POF1B in