DegronMD

Uniprot ID: Q8WVV4

Source protein: Protein POF1B

Source gene: POF1B

Class: DEG_APCC_DBOX_1

Location: 71:79

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.99

ASA_SCORE: 85.3444

COIL: 0.7293

CONS_SCORE: 0.5255

DSS_SCORE: 0.3393

HELIX: 0.084

FCONS_SCORE: 1.0707

RIG_SCORE: 0.7677

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R72W	TCGA-06-1804	GBM	TCGA	SREVLSPLK	DEG_APCC_DBOX_1	0.8634
p.R72W	DO12304	GBM	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	0.8634
p.R72L	TCGA-ER-A19P	SKCM	TCGA	SREVLSPLK	DEG_APCC_DBOX_1	0.8428
p.R72L	DO47623	SKCM	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	0.8428
p.S76F	DO218900	SKCA	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	0.7982
p.L75I	DO45229	LIRI	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	0.7174
p.E73K	DO222824	MELA	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	0.591
p.P77S	TCGA-BF-A3DM	SKCM	TCGA	SREVLSPLK	DEG_APCC_DBOX_1	0.5641
p.P77S	DO48667	SKCM	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	0.5641
p.N70D	TCGA-AJ-A3EL	UCEC	TCGA	SREVLSPLK	DEG_APCC_DBOX_1	0.3056
p.N70D	DO41542	UCEC	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	0.3056
p.T81I	TCGA-FS-A4F4	SKCM	TCGA	SREVLSPLK	DEG_APCC_DBOX_1	0.2778
p.T81I	DO37926	SKCM	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	0.2778
p.F69L	DO27817	MALY	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	0.2778
p.S83T	TCGA-D3-A8GI	SKCM	TCGA	SREVLSPLK	DEG_APCC_DBOX_1	0.2222
p.S83T	DO50284	SKCM	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	0.2222
p.Q64R	SIDM01173	Rhabdomyosarcoma	GDSC	SREVLSPLK	DEG_APCC_DBOX_1	0.1389
p.L87V	TCGA-A5-A1OF	UCEC	TCGA	SREVLSPLK	DEG_APCC_DBOX_1	0.1111
p.L87V	DO42568	UCEC	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	0.1111
p.V88I	DO221123	MALY	ICGC	SREVLSPLK	DEG_APCC_DBOX_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WVV4	Protein POF1B	DEG_APCC_DBOX_1	71:79	SREVLSPLK	APC,CDC20,FZR1	0.99	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons