DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
TMEM40
UniProt ID:
Q8WWA1
Entrez ID:
55287
Protein name:
Transmembrane protein 40
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
integral component of membrane [GO:0016021]...
integral component of membrane [GO:0016021]
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
TMEM40
Control panel
Show dataset:
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TCGA
ICGC
COSMIC
CCLE
GDSC
Show Degron:
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Degron
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Phosphorylation
Legend: PTM sites
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.E113A
TCGA-CG-5726
STAD
TCGA
LQLYGD
LIG_APCC_ABBA_1
114:119
Mutation rewiring degron network
0.3056
p.E113K
TCGA-DK-A1A3
BLCA
TCGA
LQLYGD
LIG_APCC_ABBA_1
114:119
Mutation rewiring degron network
0.3056
p.E129K
TCGA-FW-A3R5
SKCM
TCGA
LQLYGD
LIG_APCC_ABBA_1
114:119
Mutation rewiring degron network
0.0556
p.E129K
DO558
BLCA
ICGC
LQLYGD
LIG_APCC_ABBA_1
114:119
Mutation rewiring degron network
0.0556
p.E129K
SIDM00081
Melanoma
GDSC
LQLYGD
LIG_APCC_ABBA_1
114:119
Mutation rewiring degron network
0.0556
p.E129K
ACH-000615
Skin Cancer
CCLE
LQLYGD
LIG_APCC_ABBA_1
114:119
Mutation rewiring degron network
0.0556
p.E129K
SK-MEL-28
skin
COSMIC
LQLYGD
LIG_APCC_ABBA_1
114:119
Mutation rewiring degron network
0.0556
p.L110F
TCGA-GV-A3JZ
BLCA
TCGA
LQLYGD
LIG_APCC_ABBA_1
114:119
Mutation rewiring degron network
0.2222
p.V109I
TCGA-S9-A7J3
LGG
TCGA
LQLYGD
LIG_APCC_ABBA_1
114:119
Mutation rewiring degron network
0.1944
p.L126F
DO773
BLCA
ICGC
LQLYGD
LIG_APCC_ABBA_1
114:119
Mutation rewiring degron network
0.1389
p.N113I
DO8634
COAD
ICGC
LQLYGD
LIG_APCC_ABBA_1
114:119
Mutation rewiring degron network
0.3056
p.E122K
DO222597
ESCA
ICGC
LQLYGD
LIG_APCC_ABBA_1
114:119
Mutation rewiring degron network
0.25
p.V125I
DO50211
LGG
ICGC
LQLYGD
LIG_APCC_ABBA_1
114:119
Mutation rewiring degron network
0.1667
p.D124E
DO229027
LICA
ICGC
LQLYGD
LIG_APCC_ABBA_1
114:119
Mutation rewiring degron network
0.1944
p.H111Q
DO229036
LICA
ICGC
LQLYGD
LIG_APCC_ABBA_1
114:119
Mutation substituting flanking lysine
0.3611
p.A107D
DO229009
LICA
ICGC
LQLYGD
LIG_APCC_ABBA_1
114:119
Mutation rewiring degron network
0.1389
p.G119E
DO37819
SKCM
ICGC
LQLYGD
LIG_APCC_ABBA_1
114:119
Mutation altering degron motif
0.7199
p.E129A
DO38483
STAD
ICGC
LQLYGD
LIG_APCC_ABBA_1
114:119
Mutation rewiring degron network
0.0556
p.D124G
DO229259
THCA
ICGC
LQLYGD
LIG_APCC_ABBA_1
114:119
Mutation rewiring degron network
0.1944
p.G117S
DO50078
UCEC
ICGC
LQLYGD
LIG_APCC_ABBA_1
114:119
Mutation altering degron motif
0.6993
p.D108N
NCI-H1793
lung
COSMIC
LQLYGD
LIG_APCC_ABBA_1
114:119
Mutation rewiring degron network
0.1667
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for TMEM40 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc