DegronMD

Uniprot ID: Q8WWA1

Source protein: Transmembrane protein 40

Source gene: TMEM40

Class: LIG_APCC_ABBA_1

Location: 114:119

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7727

ASA_SCORE: 58.2

COIL: 0.4317

CONS_SCORE: 0.8755

DSS_SCORE: 0.6544

HELIX: 0.5533

FCONS_SCORE: 1.0327

RIG_SCORE: 0.7341

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E113A	TCGA-CG-5726	STAD	TCGA	LQLYGD	LIG_APCC_ABBA_1	0.3056
p.E113K	TCGA-DK-A1A3	BLCA	TCGA	LQLYGD	LIG_APCC_ABBA_1	0.3056
p.E129K	TCGA-FW-A3R5	SKCM	TCGA	LQLYGD	LIG_APCC_ABBA_1	0.0556
p.E129K	DO558	BLCA	ICGC	LQLYGD	LIG_APCC_ABBA_1	0.0556
p.E129K	SIDM00081	Melanoma	GDSC	LQLYGD	LIG_APCC_ABBA_1	0.0556
p.E129K	ACH-000615	Skin Cancer	CCLE	LQLYGD	LIG_APCC_ABBA_1	0.0556
p.E129K	SK-MEL-28	skin	COSMIC	LQLYGD	LIG_APCC_ABBA_1	0.0556
p.L110F	TCGA-GV-A3JZ	BLCA	TCGA	LQLYGD	LIG_APCC_ABBA_1	0.2222
p.V109I	TCGA-S9-A7J3	LGG	TCGA	LQLYGD	LIG_APCC_ABBA_1	0.1944
p.L126F	DO773	BLCA	ICGC	LQLYGD	LIG_APCC_ABBA_1	0.1389
p.N113I	DO8634	COAD	ICGC	LQLYGD	LIG_APCC_ABBA_1	0.3056
p.E122K	DO222597	ESCA	ICGC	LQLYGD	LIG_APCC_ABBA_1	0.25
p.V125I	DO50211	LGG	ICGC	LQLYGD	LIG_APCC_ABBA_1	0.1667
p.D124E	DO229027	LICA	ICGC	LQLYGD	LIG_APCC_ABBA_1	0.1944
p.H111Q	DO229036	LICA	ICGC	LQLYGD	LIG_APCC_ABBA_1	0.3611
p.A107D	DO229009	LICA	ICGC	LQLYGD	LIG_APCC_ABBA_1	0.1389
p.G119E	DO37819	SKCM	ICGC	LQLYGD	LIG_APCC_ABBA_1	0.7199
p.E129A	DO38483	STAD	ICGC	LQLYGD	LIG_APCC_ABBA_1	0.0556
p.D124G	DO229259	THCA	ICGC	LQLYGD	LIG_APCC_ABBA_1	0.1944
p.G117S	DO50078	UCEC	ICGC	LQLYGD	LIG_APCC_ABBA_1	0.6993
p.D108N	NCI-H1793	lung	COSMIC	LQLYGD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWA1	Transmembrane protein 40	LIG_APCC_ABBA_1	114:119	LQLYGD	APC,CDC20,FZR1	0.7727	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons