DegronMD - Q8WWT9(SLC13A3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G187D	TCGA-AB-2808	LAML	TCGA	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation altering degron motif	0.6087
p.G187D	DO21487	LAML	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation altering degron motif	0.6087
p.S176R	TCGA-CD-A4MG	STAD	TCGA	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.1111
p.S176R	DO48009	STAD	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.1111
p.G187S	TCGA-CK-6746	COAD	TCGA	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation altering degron motif	0.5882
p.G187S	DO7938	COAD	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation altering degron motif	0.5882
p.R184G	TCGA-D8-A1XF	BRCA	TCGA	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation altering degron motif	0.6457
p.S200N	TCGA-DX-AB2L	SARC	TCGA	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.1111
p.P198S	DO8264	COAD	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.1667
p.G184E	DO219918	DLBC	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation altering degron motif	0.7199
p.T183I	DO222837	MELA	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.3056
p.K182M	DO51517	PACA	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.2778
p.L193M	DO220011	SARC	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.3056
p.G181V	DO229462	SKCA	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.25
p.G183S	DO229502	SKCA	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.3056
p.T183A	DO219481	SKCM	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.3056
p.L185M	DO41999	UCEC	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation altering degron motif	0.711
p.T180A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.2222
p.T180A	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.2222
p.G187A	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation altering degron motif	0.6429
p.G187A	KYSE-410	oesophagus	COSMIC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation altering degron motif	0.6429
p.E178D	SIDM00259	Neuroblastoma	GDSC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.1667
p.E178D	ACH-002278	Neuroblastoma	CCLE	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.1667
p.E178D	NB10	autonomic ganglia	COSMIC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.1667
p.A182T	SIDM00954	Breast Carcinoma	GDSC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.2778
p.E177K	ACH-001566	Skin Cancer	CCLE	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.1389
p.G199D	GP5d	large intestine	COSMIC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.1389
p.T184A	YT	haematopoietic and lymphoid tissue	COSMIC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation altering degron motif	0.7139
p.R180H	DU-4475	breast	COSMIC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.2222
p.G199V	NCI-H2342	lung	COSMIC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.1389
p.H191R	MSTO-211H	pleura	COSMIC	RRNGLHTVP	DEG_APCC_DBOX_1	184:192	Mutation altering degron motif	0.8244

Kaplan plot for SLC13A3 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC13A3

UniProt ID: Q8WWT9

Entrez ID: 64849

Protein name: Solute carrier family 13 member 3 (Na(+)/dicarboxylate cotransporter 3) (NaDC-3) (hNaDC3) (Sodium-dependent high-affinity dicarboxylate transporter 2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SLC13A3 in