DegronMD

Uniprot ID: Q8WWT9

Source protein: Solute carrier family 13 member 3

Source gene: SLC13A3

Class: DEG_APCC_DBOX_1

Location: 184:192

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8764

ASA_SCORE: 88.4889

COIL: 0.7046

CONS_SCORE: 0.3127

DSS_SCORE: 0.6061

HELIX: 0.2009

FCONS_SCORE: 1.1098

RIG_SCORE: 0.6887

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H191R	MSTO-211H	pleura	COSMIC	RRNGLHTVP	DEG_APCC_DBOX_1	0.8244
p.G184E	DO219918	DLBC	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	0.7199
p.T184A	YT	haematopoietic_and_lymphoid_tissue	COSMIC	RRNGLHTVP	DEG_APCC_DBOX_1	0.7139
p.L185M	DO41999	UCEC	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	0.711
p.R184G	TCGA-D8-A1XF	BRCA	TCGA	RRNGLHTVP	DEG_APCC_DBOX_1	0.6457
p.G187A	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	RRNGLHTVP	DEG_APCC_DBOX_1	0.6429
p.G187A	KYSE-410	oesophagus	COSMIC	RRNGLHTVP	DEG_APCC_DBOX_1	0.6429
p.G187D	TCGA-AB-2808	LAML	TCGA	RRNGLHTVP	DEG_APCC_DBOX_1	0.6087
p.G187D	DO21487	LAML	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	0.6087
p.G187S	TCGA-CK-6746	COAD	TCGA	RRNGLHTVP	DEG_APCC_DBOX_1	0.5882
p.G187S	DO7938	COAD	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	0.5882
p.T183I	DO222837	MELA	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	0.3056
p.L193M	DO220011	SARC	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	0.3056
p.G183S	DO229502	SKCA	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	0.3056
p.T183A	DO219481	SKCM	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	0.3056
p.K182M	DO51517	PACA	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	0.2778
p.A182T	SIDM00954	Breast Carcinoma	GDSC	RRNGLHTVP	DEG_APCC_DBOX_1	0.2778
p.G181V	DO229462	SKCA	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	0.25
p.T180A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	RRNGLHTVP	DEG_APCC_DBOX_1	0.2222
p.T180A	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	RRNGLHTVP	DEG_APCC_DBOX_1	0.2222
p.R180H	DU-4475	breast	COSMIC	RRNGLHTVP	DEG_APCC_DBOX_1	0.2222
p.P198S	DO8264	COAD	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	0.1667
p.E178D	SIDM00259	Neuroblastoma	GDSC	RRNGLHTVP	DEG_APCC_DBOX_1	0.1667
p.E178D	ACH-002278	Neuroblastoma	CCLE	RRNGLHTVP	DEG_APCC_DBOX_1	0.1667
p.E178D	NB10	autonomic_ganglia	COSMIC	RRNGLHTVP	DEG_APCC_DBOX_1	0.1667

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Drug responses associated with SLC13A3 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of RRNGLHTVP

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWT9	Solute carrier family 13 member 3	DEG_APCC_DBOX_1	184:192	RRNGLHTVP	APC,CDC20,FZR1	0.8764	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRNGLHTVP

Degron related mutations and impact score

Drug responses associated with SLC13A3 mutations

All proteins holding degron of RRNGLHTVP