DegronMD

Uniprot ID: Q8WWT9

Source protein: Solute carrier family 13 member 3

Source gene: SLC13A3

Class: DEG_APCC_DBOX_1

Location: 184:192

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8764

ASA_SCORE: 88.4889

COIL: 0.7046

CONS_SCORE: 0.3127

DSS_SCORE: 0.6061

HELIX: 0.2009

FCONS_SCORE: 1.1098

RIG_SCORE: 0.6887

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G187D	TCGA-AB-2808	LAML	TCGA	RRNGLHTVP	DEG_APCC_DBOX_1	0.6087
p.G187D	DO21487	LAML	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	0.6087
p.S176R	TCGA-CD-A4MG	STAD	TCGA	RRNGLHTVP	DEG_APCC_DBOX_1	0.1111
p.S176R	DO48009	STAD	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	0.1111
p.G187S	TCGA-CK-6746	COAD	TCGA	RRNGLHTVP	DEG_APCC_DBOX_1	0.5882
p.G187S	DO7938	COAD	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	0.5882
p.R184G	TCGA-D8-A1XF	BRCA	TCGA	RRNGLHTVP	DEG_APCC_DBOX_1	0.6457
p.S200N	TCGA-DX-AB2L	SARC	TCGA	RRNGLHTVP	DEG_APCC_DBOX_1	0.1111
p.P198S	DO8264	COAD	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	0.1667
p.G184E	DO219918	DLBC	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	0.7199
p.T183I	DO222837	MELA	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	0.3056
p.K182M	DO51517	PACA	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	0.2778
p.L193M	DO220011	SARC	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	0.3056
p.G181V	DO229462	SKCA	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	0.25
p.G183S	DO229502	SKCA	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	0.3056
p.T183A	DO219481	SKCM	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	0.3056
p.L185M	DO41999	UCEC	ICGC	RRNGLHTVP	DEG_APCC_DBOX_1	0.711
p.T180A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	RRNGLHTVP	DEG_APCC_DBOX_1	0.2222
p.T180A	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	RRNGLHTVP	DEG_APCC_DBOX_1	0.2222
p.G187A	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	RRNGLHTVP	DEG_APCC_DBOX_1	0.6429
p.G187A	KYSE-410	oesophagus	COSMIC	RRNGLHTVP	DEG_APCC_DBOX_1	0.6429
p.E178D	SIDM00259	Neuroblastoma	GDSC	RRNGLHTVP	DEG_APCC_DBOX_1	0.1667
p.E178D	ACH-002278	Neuroblastoma	CCLE	RRNGLHTVP	DEG_APCC_DBOX_1	0.1667
p.E178D	NB10	autonomic_ganglia	COSMIC	RRNGLHTVP	DEG_APCC_DBOX_1	0.1667
p.A182T	SIDM00954	Breast Carcinoma	GDSC	RRNGLHTVP	DEG_APCC_DBOX_1	0.2778
p.E177K	ACH-001566	Skin Cancer	CCLE	RRNGLHTVP	DEG_APCC_DBOX_1	0.1389
p.G199D	GP5d	large_intestine	COSMIC	RRNGLHTVP	DEG_APCC_DBOX_1	0.1389
p.T184A	YT	haematopoietic_and_lymphoid_tissue	COSMIC	RRNGLHTVP	DEG_APCC_DBOX_1	0.7139
p.R180H	DU-4475	breast	COSMIC	RRNGLHTVP	DEG_APCC_DBOX_1	0.2222
p.G199V	NCI-H2342	lung	COSMIC	RRNGLHTVP	DEG_APCC_DBOX_1	0.1389
p.H191R	MSTO-211H	pleura	COSMIC	RRNGLHTVP	DEG_APCC_DBOX_1	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRNGLHTVP

Degron related mutations and impact score

Drug responses associated with SLC13A3 mutations

All proteins holding degron of RRNGLHTVP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWT9	Solute carrier family 13 member 3	DEG_APCC_DBOX_1	184:192	RRNGLHTVP	APC,CDC20,FZR1	0.8764	More...