DegronMD - Q8WWV6(FCAMR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P224R	TCGA-C8-A8HQ	BRCA	TCGA	VASTPGTS	DEG_SCF_FBW7_1	220:227	Mutation altering degron motif	0.7512
p.P224R	DO219623	BRCA	ICGC	VASTPGTS	DEG_SCF_FBW7_1	220:227	Mutation altering degron motif	0.7512
p.G218S	TCGA-FW-A3R5	SKCM	TCGA	VASTPGTS	DEG_SCF_FBW7_1	220:227	Mutation rewiring degron network	0.2778
p.V218A	DO222427	BTCA	ICGC	VASTPGTS	DEG_SCF_FBW7_1	220:227	Mutation rewiring degron network	0.2778
p.V218A	DO42913	UCEC	ICGC	VASTPGTS	DEG_SCF_FBW7_1	220:227	Mutation rewiring degron network	0.2778
p.W237L	DO231954	LICA	ICGC	VASTPGTS	DEG_SCF_FBW7_1	220:227	Mutation rewiring degron network	0.0556
p.P229L	DO222599	MELA	ICGC	VASTPGTS	DEG_SCF_FBW7_1	220:227	Mutation rewiring degron network	0.2778
p.P229L	DO37835	SKCM	ICGC	VASTPGTS	DEG_SCF_FBW7_1	220:227	Mutation rewiring degron network	0.2778
p.P228L	DO222635	MELA	ICGC	VASTPGTS	DEG_SCF_FBW7_1	220:227	Mutation rewiring degron network	0.3056
p.S233P	DO232761	PBCA	ICGC	VASTPGTS	DEG_SCF_FBW7_1	220:227	Mutation rewiring degron network	0.1667
p.M223I	DO37819	SKCM	ICGC	VASTPGTS	DEG_SCF_FBW7_1	220:227	Mutation altering degron motif	0.7618
p.V218I	DO37406	SKCM	ICGC	VASTPGTS	DEG_SCF_FBW7_1	220:227	Mutation rewiring degron network	0.2778
p.S233Y	DO41799	UCEC	ICGC	VASTPGTS	DEG_SCF_FBW7_1	220:227	Mutation rewiring degron network	0.1667
p.S210G	SIDM01951	Colorectal Carcinoma	GDSC	VASTPGTS	DEG_SCF_FBW7_1	220:227	Mutation rewiring degron network	0.0556
p.A217E	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	VASTPGTS	DEG_SCF_FBW7_1	220:227	Mutation rewiring degron network	0.25
p.A217T	SIDM01130	Squamous Cell Lung Carcinoma	GDSC	VASTPGTS	DEG_SCF_FBW7_1	220:227	Mutation rewiring degron network	0.25
p.A217T	ACH-000395	Lung Cancer	CCLE	VASTPGTS	DEG_SCF_FBW7_1	220:227	Mutation rewiring degron network	0.25
p.A217T	NCI-H520	lung	COSMIC	VASTPGTS	DEG_SCF_FBW7_1	220:227	Mutation rewiring degron network	0.25

Kaplan plot for FCAMR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FCAMR

UniProt ID: Q8WWV6

Entrez ID: 83953

Protein name: High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor (Fc alpha/mu receptor) (CD antigen CD351)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FCAMR in