DegronMD

Uniprot ID: Q8WWV6

Source protein: High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor

Source gene: FCAMR

Class: DEG_SCF_FBW7_1

Location: 220:227

E3 ligase: FBXW7

DEGRON score: 0.8656

ASA_SCORE: 55.0625

COIL: 0.643

CONS_SCORE: 0.6728

DSS_SCORE: 0.6281

HELIX: 0.0345

FCONS_SCORE: 0.9561

RIG_SCORE: 0.6818

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P224R	TCGA-C8-A8HQ	BRCA	TCGA	VASTPGTS	DEG_SCF_FBW7_1	0.7512
p.P224R	DO219623	BRCA	ICGC	VASTPGTS	DEG_SCF_FBW7_1	0.7512
p.G218S	TCGA-FW-A3R5	SKCM	TCGA	VASTPGTS	DEG_SCF_FBW7_1	0.2778
p.V218A	DO222427	BTCA	ICGC	VASTPGTS	DEG_SCF_FBW7_1	0.2778
p.V218A	DO42913	UCEC	ICGC	VASTPGTS	DEG_SCF_FBW7_1	0.2778
p.W237L	DO231954	LICA	ICGC	VASTPGTS	DEG_SCF_FBW7_1	0.0556
p.P229L	DO222599	MELA	ICGC	VASTPGTS	DEG_SCF_FBW7_1	0.2778
p.P229L	DO37835	SKCM	ICGC	VASTPGTS	DEG_SCF_FBW7_1	0.2778
p.P228L	DO222635	MELA	ICGC	VASTPGTS	DEG_SCF_FBW7_1	0.3056
p.S233P	DO232761	PBCA	ICGC	VASTPGTS	DEG_SCF_FBW7_1	0.1667
p.M223I	DO37819	SKCM	ICGC	VASTPGTS	DEG_SCF_FBW7_1	0.7618
p.V218I	DO37406	SKCM	ICGC	VASTPGTS	DEG_SCF_FBW7_1	0.2778
p.S233Y	DO41799	UCEC	ICGC	VASTPGTS	DEG_SCF_FBW7_1	0.1667
p.S210G	SIDM01951	Colorectal Carcinoma	GDSC	VASTPGTS	DEG_SCF_FBW7_1	0.0556
p.A217E	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	VASTPGTS	DEG_SCF_FBW7_1	0.25
p.A217T	SIDM01130	Squamous Cell Lung Carcinoma	GDSC	VASTPGTS	DEG_SCF_FBW7_1	0.25
p.A217T	ACH-000395	Lung Cancer	CCLE	VASTPGTS	DEG_SCF_FBW7_1	0.25
p.A217T	NCI-H520	lung	COSMIC	VASTPGTS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWV6	High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor	DEG_SCF_FBW7_1	220:227	VASTPGTS	FBXW7	0.8656	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons