DegronMD - Q8WX77(IGFBPL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G169V	TCGA-44-2656	LUAD	TCGA	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation rewiring degron network	0.1667
p.G169V	DO26052	LUAD	ICGC	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation rewiring degron network	0.1667
p.E177D	TCGA-A5-A0GU	UCEC	TCGA	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation altering degron motif	0.5647
p.E177D	DO43266	UCEC	ICGC	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation altering degron motif	0.5647
p.T183I	TCGA-AP-A0LM	UCEC	TCGA	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation altering degron motif	0.7078
p.T183I	DO43306	UCEC	ICGC	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation altering degron motif	0.7078
p.T183A	TCGA-DI-A1BU	UCEC	TCGA	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation altering degron motif	0.7139
p.T183A	DO42023	UCEC	ICGC	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation altering degron motif	0.7139
p.V172M	TCGA-EE-A2A2	SKCM	TCGA	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation rewiring degron network	0.25
p.V172M	DO37583	SKCM	ICGC	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation rewiring degron network	0.25
p.N166T	TCGA-EO-A22U	UCEC	TCGA	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation rewiring degron network	0.0833
p.N166T	DO43755	UCEC	ICGC	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation rewiring degron network	0.0833
p.A180V	TCGA-EO-A3B0	UCEC	TCGA	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation altering degron motif	0.5825
p.A180V	TCGA-XK-AAIW	PRAD	TCGA	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation altering degron motif	0.5825
p.A180V	DO51407	PRAD	ICGC	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation altering degron motif	0.5825
p.A180V	DO219773	UCEC	ICGC	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation altering degron motif	0.5825
p.T187A	TCGA-FI-A2D5	UCEC	TCGA	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation rewiring degron network	0.25
p.T187A	DO41331	UCEC	ICGC	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation rewiring degron network	0.25
p.K190N	TCGA-GF-A2C7	SKCM	TCGA	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation substituting flanking lysine	0.2778
p.K190N	DO37407	SKCM	ICGC	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation substituting flanking lysine	0.2778
p.T192A	TCGA-RD-A8NB	STAD	TCGA	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation rewiring degron network	0.1111
p.T192A	DO50142	STAD	ICGC	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation rewiring degron network	0.1111
p.T187M	DO229050	LICA	ICGC	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation rewiring degron network	0.25
p.G173V	SIDM00672	Hepatocellular Carcinoma	GDSC	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation rewiring degron network	0.2778
p.G173V	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation rewiring degron network	0.2778
p.G173V	SIDM00254	Neuroblastoma	GDSC	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation rewiring degron network	0.2778
p.G173R	SIDM00858	Osteosarcoma	GDSC	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation rewiring degron network	0.2778
p.G173R	ACH-000082	bone	CCLE	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation rewiring degron network	0.2778
p.G173R	G-292_Clone_A141B1	bone	COSMIC	SCEVRAVPTP	DEG_COP1_1	175:184	Mutation rewiring degron network	0.2778

Kaplan plot for IGFBPL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IGFBPL1

UniProt ID: Q8WX77

Entrez ID: 347252

Protein name: Insulin-like growth factor-binding protein-like 1 (IGFBP-related protein 10) (Insulin-like growth factor-binding-related protein 4) (IGFBP-rP4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IGFBPL1 in