DegronMD

Uniprot ID: Q8WX77

Source protein: Insulin-like growth factor-binding protein-like 1

Source gene: IGFBPL1

Class: DEG_COP1_1

Location: 175:184

E3 ligase: COP1

DEGRON score: 0.6995

ASA_SCORE: 46.95

COIL: 0.4943

CONS_SCORE: 0.7203

DSS_SCORE: 0.2268

HELIX: 0.0045

FCONS_SCORE: 1.3278

RIG_SCORE: 0.8237

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G169V	TCGA-44-2656	LUAD	TCGA	SCEVRAVPTP	DEG_COP1_1	0.1667
p.G169V	DO26052	LUAD	ICGC	SCEVRAVPTP	DEG_COP1_1	0.1667
p.E177D	TCGA-A5-A0GU	UCEC	TCGA	SCEVRAVPTP	DEG_COP1_1	0.5647
p.E177D	DO43266	UCEC	ICGC	SCEVRAVPTP	DEG_COP1_1	0.5647
p.T183I	TCGA-AP-A0LM	UCEC	TCGA	SCEVRAVPTP	DEG_COP1_1	0.7078
p.T183I	DO43306	UCEC	ICGC	SCEVRAVPTP	DEG_COP1_1	0.7078
p.T183A	TCGA-DI-A1BU	UCEC	TCGA	SCEVRAVPTP	DEG_COP1_1	0.7139
p.T183A	DO42023	UCEC	ICGC	SCEVRAVPTP	DEG_COP1_1	0.7139
p.V172M	TCGA-EE-A2A2	SKCM	TCGA	SCEVRAVPTP	DEG_COP1_1	0.25
p.V172M	DO37583	SKCM	ICGC	SCEVRAVPTP	DEG_COP1_1	0.25
p.N166T	TCGA-EO-A22U	UCEC	TCGA	SCEVRAVPTP	DEG_COP1_1	0.0833
p.N166T	DO43755	UCEC	ICGC	SCEVRAVPTP	DEG_COP1_1	0.0833
p.A180V	TCGA-EO-A3B0	UCEC	TCGA	SCEVRAVPTP	DEG_COP1_1	0.5825
p.A180V	TCGA-XK-AAIW	PRAD	TCGA	SCEVRAVPTP	DEG_COP1_1	0.5825
p.A180V	DO51407	PRAD	ICGC	SCEVRAVPTP	DEG_COP1_1	0.5825
p.A180V	DO219773	UCEC	ICGC	SCEVRAVPTP	DEG_COP1_1	0.5825
p.T187A	TCGA-FI-A2D5	UCEC	TCGA	SCEVRAVPTP	DEG_COP1_1	0.25
p.T187A	DO41331	UCEC	ICGC	SCEVRAVPTP	DEG_COP1_1	0.25
p.K190N	TCGA-GF-A2C7	SKCM	TCGA	SCEVRAVPTP	DEG_COP1_1	0.2778
p.K190N	DO37407	SKCM	ICGC	SCEVRAVPTP	DEG_COP1_1	0.2778
p.T192A	TCGA-RD-A8NB	STAD	TCGA	SCEVRAVPTP	DEG_COP1_1	0.1111
p.T192A	DO50142	STAD	ICGC	SCEVRAVPTP	DEG_COP1_1	0.1111
p.T187M	DO229050	LICA	ICGC	SCEVRAVPTP	DEG_COP1_1	0.25
p.G173V	SIDM00672	Hepatocellular Carcinoma	GDSC	SCEVRAVPTP	DEG_COP1_1	0.2778
p.G173V	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	SCEVRAVPTP	DEG_COP1_1	0.2778
p.G173V	SIDM00254	Neuroblastoma	GDSC	SCEVRAVPTP	DEG_COP1_1	0.2778
p.G173R	SIDM00858	Osteosarcoma	GDSC	SCEVRAVPTP	DEG_COP1_1	0.2778
p.G173R	ACH-000082	bone	CCLE	SCEVRAVPTP	DEG_COP1_1	0.2778
p.G173R	G-292_Clone_A141B1	bone	COSMIC	SCEVRAVPTP	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WX77	Insulin-like growth factor-binding protein-like 1	DEG_COP1_1	175:184	SCEVRAVPTP	COP1	0.6995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SCEVRAVPTP

Degron related mutations and impact score

Drug responses associated with IGFBPL1 mutations

All proteins holding degron of SCEVRAVPTP