DegronMD - Q8WXK1(ASB15)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R571I	TCGA-19-5956	GBM	TCGA	RYILFKE	LIG_APCC_ABBAyCdc20_2	571:577	Mutation altering degron motif	0.8102
p.R571I	DO13863	GBM	ICGC	RYILFKE	LIG_APCC_ABBAyCdc20_2	571:577	Mutation altering degron motif	0.8102
p.E577Q	TCGA-85-8070	LUSC	TCGA	RYILFKE	LIG_APCC_ABBAyCdc20_2	571:577	Mutation altering degron motif	0.6744
p.E577Q	DO26581	LUSC	ICGC	RYILFKE	LIG_APCC_ABBAyCdc20_2	571:577	Mutation altering degron motif	0.6744
p.G582E	TCGA-A6-6780	COAD	TCGA	RYILFKE	LIG_APCC_ABBAyCdc20_2	571:577	Mutation rewiring degron network	0.1944
p.G582E	DO10244	COAD	ICGC	RYILFKE	LIG_APCC_ABBAyCdc20_2	571:577	Mutation rewiring degron network	0.1944
p.A568V	TCGA-AP-A1E0	UCEC	TCGA	RYILFKE	LIG_APCC_ABBAyCdc20_2	571:577	Mutation rewiring degron network	0.25
p.A568V	DO43154	UCEC	ICGC	RYILFKE	LIG_APCC_ABBAyCdc20_2	571:577	Mutation rewiring degron network	0.25
p.Y572C	TCGA-B5-A11E	UCEC	TCGA	RYILFKE	LIG_APCC_ABBAyCdc20_2	571:577	Mutation altering degron motif	0.5976
p.Y572C	DO41644	UCEC	ICGC	RYILFKE	LIG_APCC_ABBAyCdc20_2	571:577	Mutation altering degron motif	0.5976
p.F575V	TCGA-D1-A16Y	UCEC	TCGA	RYILFKE	LIG_APCC_ABBAyCdc20_2	571:577	Mutation altering degron motif	0.7068
p.F575V	DO41524	UCEC	ICGC	RYILFKE	LIG_APCC_ABBAyCdc20_2	571:577	Mutation altering degron motif	0.7068
p.G582R	TCGA-EE-A2MG	SKCM	TCGA	RYILFKE	LIG_APCC_ABBAyCdc20_2	571:577	Mutation rewiring degron network	0.1944
p.G582R	DO37421	SKCM	ICGC	RYILFKE	LIG_APCC_ABBAyCdc20_2	571:577	Mutation rewiring degron network	0.1944
p.L565V	DO225209	BRCA	ICGC	RYILFKE	LIG_APCC_ABBAyCdc20_2	571:577	Mutation rewiring degron network	0.1667
p.Q570H	DO220850	MELA	ICGC	RYILFKE	LIG_APCC_ABBAyCdc20_2	571:577	Mutation rewiring degron network	0.3056
p.D579G	SIDM00193	Colorectal Carcinoma	GDSC	RYILFKE	LIG_APCC_ABBAyCdc20_2	571:577	Mutation rewiring degron network	0.2778
p.D579G	ACH-000991	Colon/Colorectal Cancer	CCLE	RYILFKE	LIG_APCC_ABBAyCdc20_2	571:577	Mutation rewiring degron network	0.2778
p.D579G	SNU-81	large intestine	COSMIC	RYILFKE	LIG_APCC_ABBAyCdc20_2	571:577	Mutation rewiring degron network	0.2778

Kaplan plot for ASB15 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ASB15

UniProt ID: Q8WXK1

Entrez ID: 142685

Protein name: Ankyrin repeat and SOCS box protein 15 (ASB-15)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ASB15 in