DegronMD

Uniprot ID: Q8WXK1

Source protein: Ankyrin repeat and SOCS box protein 15

Source gene: ASB15

Class: LIG_APCC_ABBAyCdc20_2

Location: 571:577

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6067

ASA_SCORE: 66.4

COIL: 0.2004

CONS_SCORE: 0.5692

DSS_SCORE: 0.0509

HELIX: 0.7746

FCONS_SCORE: 1.2993

RIG_SCORE: 0.9391

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R571I	TCGA-19-5956	GBM	TCGA	RYILFKE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R571I	DO13863	GBM	ICGC	RYILFKE	LIG_APCC_ABBAyCdc20_2	0.8102
p.E577Q	TCGA-85-8070	LUSC	TCGA	RYILFKE	LIG_APCC_ABBAyCdc20_2	0.6744
p.E577Q	DO26581	LUSC	ICGC	RYILFKE	LIG_APCC_ABBAyCdc20_2	0.6744
p.G582E	TCGA-A6-6780	COAD	TCGA	RYILFKE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G582E	DO10244	COAD	ICGC	RYILFKE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A568V	TCGA-AP-A1E0	UCEC	TCGA	RYILFKE	LIG_APCC_ABBAyCdc20_2	0.25
p.A568V	DO43154	UCEC	ICGC	RYILFKE	LIG_APCC_ABBAyCdc20_2	0.25
p.Y572C	TCGA-B5-A11E	UCEC	TCGA	RYILFKE	LIG_APCC_ABBAyCdc20_2	0.5976
p.Y572C	DO41644	UCEC	ICGC	RYILFKE	LIG_APCC_ABBAyCdc20_2	0.5976
p.F575V	TCGA-D1-A16Y	UCEC	TCGA	RYILFKE	LIG_APCC_ABBAyCdc20_2	0.7068
p.F575V	DO41524	UCEC	ICGC	RYILFKE	LIG_APCC_ABBAyCdc20_2	0.7068
p.G582R	TCGA-EE-A2MG	SKCM	TCGA	RYILFKE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G582R	DO37421	SKCM	ICGC	RYILFKE	LIG_APCC_ABBAyCdc20_2	0.1944
p.L565V	DO225209	BRCA	ICGC	RYILFKE	LIG_APCC_ABBAyCdc20_2	0.1667
p.Q570H	DO220850	MELA	ICGC	RYILFKE	LIG_APCC_ABBAyCdc20_2	0.3056
p.D579G	SIDM00193	Colorectal Carcinoma	GDSC	RYILFKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.D579G	ACH-000991	Colon/Colorectal Cancer	CCLE	RYILFKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.D579G	SNU-81	large_intestine	COSMIC	RYILFKE	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXK1	Ankyrin repeat and SOCS box protein 15	LIG_APCC_ABBAyCdc20_2	571:577	RYILFKE	APC,CDC20,FZR1	0.6067	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons