DegronMD - Q8WXR4(MYO3B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1104W	TCGA-19-5956	GBM	TCGA	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation altering degron motif	0.8634
p.R1104W	SIDM00628	Breast Carcinoma	GDSC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation altering degron motif	0.8634
p.R1104W	MDA-MB-468	breast	COSMIC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation altering degron motif	0.8634
p.K1109R	TCGA-32-2491	GBM	TCGA	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation substituting flanking lysine	0.3056
p.E1088V	TCGA-AD-6964	COAD	TCGA	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation rewiring degron network	0.1667
p.E1088V	DO8360	COAD	ICGC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation rewiring degron network	0.1667
p.E1085K	TCGA-BH-A18P	BRCA	TCGA	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation rewiring degron network	0.0833
p.E1085K	DO3346	BRCA	ICGC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation rewiring degron network	0.0833
p.E1085V	TCGA-BH-A18P	BRCA	TCGA	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation rewiring degron network	0.0833
p.E1085V	DO3346	BRCA	ICGC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation rewiring degron network	0.0833
p.G1100E	TCGA-EB-A4XL	SKCM	TCGA	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation altering degron motif	0.7199
p.W1098C	TCGA-G3-A25W	LIHC	TCGA	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation altering degron motif	0.5889
p.I1110M	TCGA-GN-A266	SKCM	TCGA	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation rewiring degron network	0.1667
p.A1111T	DO9114	COAD	ICGC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation rewiring degron network	0.1389
p.A1111T	DO38703	STAD	ICGC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation rewiring degron network	0.1389
p.Q1095R	DO8264	COAD	ICGC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation altering degron motif	0.7329
p.T1099A	DO234462	ESAD	ICGC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation altering degron motif	0.7139
p.R1113Q	DO233090	GACA	ICGC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation rewiring degron network	0.0833
p.R1113W	DO13863	GBM	ICGC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation rewiring degron network	0.0833
p.K1086N	DO229029	LICA	ICGC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation substituting flanking lysine	0.2222
p.W1107C	DO22970	LIHC	ICGC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation rewiring degron network	0.25
p.T1114M	DO219165	LUSC	ICGC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation rewiring degron network	0.0556
p.G1109E	DO222824	MELA	ICGC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation substituting flanking lysine	0.3056
p.G1109E	DO47401	SKCM	ICGC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation substituting flanking lysine	0.3056
p.P1109S	DO222837	MELA	ICGC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation substituting flanking lysine	0.3056
p.P1109S	NB10	autonomic ganglia	COSMIC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation substituting flanking lysine	0.3056
p.E1085D	DO232832	NACA	ICGC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation rewiring degron network	0.0833
p.G1113D	DO37911	SKCM	ICGC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation rewiring degron network	0.0833
p.D1098G	DO41331	UCEC	ICGC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation altering degron motif	0.7198
p.A1091V	SIDM00958	Chronic Myelogenous Leukemia	GDSC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation rewiring degron network	0.25
p.A1091V	ACH-000920	Leukemia	CCLE	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation rewiring degron network	0.25
p.A1091V	CML-T1	haematopoietic and lymphoid tissue	COSMIC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation rewiring degron network	0.25
p.A1112S	NCI-H1838	lung	COSMIC	IQSAWRGYDAR	SCF_FBXL2	1094:1104	Mutation rewiring degron network	0.1111

Kaplan plot for MYO3B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYO3B

UniProt ID: Q8WXR4

Entrez ID: 140469

Protein name: Myosin-IIIb (EC 2.7.11.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYO3B in